Abstract

This compilation of research examines the multifaceted nature of powder flowability, a key attribute in pharmaceutical manufacturing. It delves into the impact of intrinsic particle characteristics such as shape, size distribution, and surface properties, alongside external factors like moisture content and electrostatic charges. The role of excipients, specifically glidants, in enhancing flow is explored. Furthermore, the application of advanced characterization techniques, including rheology and computational fluid dynamics (CFD), for predicting and optimizing powder behavior is highlighted. Strategies for improving the flow of challenging powders through surface functionalization and managing issues like segregation in mixtures are also discussed.