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Preliminary Findings on the Effects of Interferon-and#945; Treatment on Human Papilloma virus Infection in a Small Pilot Study of HIV and Hepatitis C Virus Co-Infected Men | Abstract
ISSN: 2161-1165

Epidemiology: Open Access
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Research Article

Preliminary Findings on the Effects of Interferon-α Treatment on Human Papilloma virus Infection in a Small Pilot Study of HIV and Hepatitis C Virus Co-Infected Men

E. Susan Amirian1,2, Elizabeth Y. Chiao3, Kirk T. Hill3, Deborah Marquez-Do2 and Michael E. Scheurer1,2*

1Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA

2Dan L Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA

3Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA

*Corresponding Author:
Michael E Scheurer
Department of Pediatrics
Baylor College of Medicine
One Baylor Plaza, Houston, TX 77030, USA
Tel: 713-798-5547
Fax: 713-798-8711
E-mail: [email protected]

Received date: August 27, 2013; Accepted date: October 28, 2013; Published date: October 30, 2013

Citation: Susan Amirian E, Chiao EY, Hill KT, Marquez-Do D, Scheurer ME (2013) Preliminary Findings on the Effects of Interferon-α Treatment on Human Papilloma virus Infection in a Small Pilot Study of HIV and Hepatitis C Virus Co-Infected Men. Epidemiol 3:139. doi:10.4172/2161-1165.1000139

Copyright: © 2013 Susan Amirian E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Human Papilloma Virus (HPV) has been etiologically linked with a number of different cancers. A few older studies have evaluated the effects of Interferon-alpha (IFN-α) treatment on HPV infection and HPV-related dysplasia. However, findings from these studies may not be generalizable to the more recent formulations of IFN-α that are now used to treat Hepatitis C Virus (HCV) infection. The purpose of this small pilot study was to assess whether treatment for HCV by pegylated, rather than standard, IFN-α was associated with the presence of or distribution of the types of HPV found in the oral, penile, and anal regions of HIV and HCV co-infected men. A total of 33 men were enrolled in this pilot study. Of these, 10 were in the IFN-α-exposed group and 23 were in the IFN-α-naïve comparison group. The IFN-α-naïve group had a higher average number of different HPV types present in penile and oral swabs, but not in anal swabs, compared to the treated group. The results of this small pilot study are preliminary. However, our findings have provided some rationale for continuing to explore whether pegylated IFN-α may be a useful adjuvant therapy, or whether it could be combined with other treatment modalities for controlling HPV infection (or disease), specifically of the penis or oral mucosa, among high-risk and HIV-Infected populations.

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