alexa Primary Oral Melanoma: A Case Report with Immunohistoch
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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Case Report

Primary Oral Melanoma: A Case Report with Immunohistochemical Findings

Juliana de Souza do Nascimento1, Adalberto Mosqueda Taylor2, Oslei Paes de Almeida3 and Bruno Augusto Benevenuto de Andrade4*

1School of Dentistry, Fluminense Federal University (UFF), Nova Friburgo, Rio de Janeiro, Brazil

2Department of Health Care, Metropolitan Autonomous University Xochimilco, México

3Oral Pathology, School of Dentistry, State University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil

4Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil

*Corresponding Author:
Bruno Augusto Benevenuto de Andrade
DDS, PhD, Department of Oral Diagnosis and Pathology
School of Dentistry, Federal University of Rio de Janeiro (UFRJ)
Rio de Janeiro, Brazil
Tel: +55 21 25622071
Fax: +55 21 25622071
E-mail: [email protected]

Received date: September 30, 2014; Accepted date: October 16, 2014; Published date: October 19, 2014

Citation: Nascimento JS, Taylor AM, Almeida OP, Andrade BAB (2014) Primary Oral Melanoma: A Case Report with Immunohistochemical Findings. J Clin Exp Pathol 4:197. doi:10.4172/2161-0681.1000197

Copyright: ©2014 Nascimento JS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Melanoma is a potentially aggressive and rare malign neoplasm of melanocytic origin. Only 1% occurs in oral mucosa, accounting for 0.5% of all oral malignancies being more aggressive when compared with the cutaneous counterpart. The tumor occurs more frequently in the hard palate and gingiva. Despite the advances in biological knowledge of melanoma, treatment and prognosis still have limitations, especially in head and neck melanomas, including oral melanomas. The aim of this study is to report a case of primary oral melanoma in a 54 year-old male patient. An asymptomatic pigmented lesion was located in the upper vestibular gingiva and an incisional biopsy was done. Cytomorphological findings revealed proliferation of pleomorphic epithelioid and plasmacytoid cells positive by immunohistochemistry for S-100 protein, HMB-45 and Melan-A, confirming the diagnostic of oral melanoma. This study showed the importance of the histopathological and immunohistochemical evaluation in order to determine the cytomorphologic aspects of oral melanoma to establish the final diagnosis.


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