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ISSN: 2476-2024

Diagnostic Pathology: Open Access
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  • Research Article   
  • Diagn Pathol Open 2017, Vol 2(2): 127
  • DOI: 10.4172/2476-2024.1000127

Prognostic and Predictive Values of cell Cycle Proteins Centrosomal Protein 5 (CEPP 5)

Ola Harb1*, Ibtesam Elhasadi2, Sharifa AM El.Ammari2, Amal Inbaig2, Rema H Faraj Saad2, Rham Z Ahmed3 and Safa A Balata4
1Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department of Pathology, Faculty of Medicine, Benghazi University, Benghazi, Libya
3Department of Medical Oncology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt
*Corresponding Author : Ola Harb, Department of Pathology, Faculty of Medicine, Zagazig University, Zagazig, 44519, Egypt, Tel: 01224963123, Email: [email protected]

Received Date: Sep 19, 2017 / Accepted Date: Oct 09, 2017 / Published Date: Oct 19, 2017

Abstract

Background: Disturbances in the expressions of centrosomal proteins (CEPs) and regulatory proteins that control G1-Sphase transition, like cyclins could participate in dysregulation of cell cycle control that has been incriminated in the pathogenesis of several malignancies. Centrosomal protein 55 (CEP55) has an important role in participation in the final stage of cell division, and cell cycle progression. CEP55 and Cyclin D1 expressions were detected in several tumors but their prognostic and predictive roles in epithelial ovarian carcinoma (EOC) are still studied.

Aim of the study: Explore tissue expressions of CEPP55 and Cyclin D1 in EOC correlating their expression with pathological, clinical and prognostic parameters.

Methods: CEP55 and Cyclin D1 expressions were evaluated in tissue biopsies that are retrieved from 60 cases of epithelial ovarian carcinoma using immunohistochemistry, patients that were followed up for 3 years. The relationship between their level of expressions and degree of differentiation, spread of the tumor, disease recurrence, response to therapy and survival were studied.

Results: CEP55 expression in EOC was positively correlated with loss of differentiation of the tumor, presence of L.N (p<0.001), and distant metastases (p=0.012) and advanced stage of the tumor (p=0.007), cyclin D1 expression in EOC was positively correlated with loss of differentiation and advanced stage of the tumor, presence of L.N (p<0.001), and distant metastases (p=0.009). CEPP 55 and Cyclin D1 were positively correlated with each other. Low CEPP 55 and Cyclin D1 expressions were strongly correlated with optimal surgical eradication of the tumor, increased 3-year overall survival (OS) and low incidence of tumor recurrence after therapy (P<0.001).

Conclusion: High levels of expression of CEPP 55 and Cyclin D1and are markers of poor prognosis in EOC patients.

Keywords: CEP55; Cyclin D1 epithelial ovarian carcinoma; Prognosfis

Citation: Harb O, Elhasadi I, El.Ammari SAM, Inbaig A, Saad RHF, et al. (2017) Prognostic and Predictive Values of cell Cycle Proteins Centrosomal Protein 5 (CEPP 5) and Cyclin D1 Expression in Epithelial Ovarian Carcinoma (EOC). Diagn Pathol Open 2: 127. Doi: 10.4172/2476-2024.1000127

Copyright: ©2017 Harb O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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