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Proposal for Insulinogenic Index (IGI)-Carbo70 as Experimental Evaluation for Diabetes | OMICS International| Abstract

Journal of Clinical and Experimental Endocrinology
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  • Research Article   
  • J Clin Exp Endocrinol, Vol 1(1): 102

Proposal for Insulinogenic Index (IGI)-Carbo70 as Experimental Evaluation for Diabetes

Hiroshi Bando1*, Ebe K2, Muneta T3, Bando M4 and Yonei Y5
1Medical Research, Tokushima University, Tokushima, Japan
2Takao Hospital, , Kyoto, Japan
3Muneta Maternity Clinic, , Chiba, Japan
4Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University, Tokushima, Japan
5Anti-Aging Medical Research Center, Graduate School of Life and Medical Sciences, Doshisha university, Kyoto, Japan
*Corresponding Author : Hiroshi Bando, Instructor, Tokushima University, Nakashowa 1-61, Tokushima 770-0943, Japan, Tel: +81-90-3187-2485, Email: [email protected]

Received Date: Oct 09, 2017 / Accepted Date: Oct 11, 2017 / Published Date: Nov 18, 2017

Abstract

Background: The discussion has continued concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD) for years. Authors and colleagues have continued clinical research on LCD. In this study, CR diet was given to diabetic patients and the new evaluation way of insulinogenic index-carbohydrate 70 g (IGI-carbo70) would be proposed.
Subjects and methods: The subjects were 48 patients with Type 2 diabetes mellitus (T2DM) and admitted for 14 days for further evaluation and treatment. CR diet was provided on day 1 and 2, including 60% carbohydrate, 25% lipids and 15% protein with 1400 kcal/day. On the morning of day 2, breakfast with 70 g of carbohydrate was given, and blood glucose and immune reactive insulin (IRI) at 0 and 30 min and IGI were investigated.
Results: Average HbA1c was 7.9% and Morbus (M) value was 108 in median. Glucose and IRI on 0-30 min significantly increased as 166-212 mg/dL, 4.3-1.9 μU/mL, respectively. Classified into 3 groups as to HbA1c level, low, middle and high group showed HbA1c 6.0%, 7.8%, 9.7%, respectively. Glucose and IRI on 0-30 min in median were 117-50, 166-203, 218-299 mg/dL, 4.4-12.8, 4.5-13.5, 4.2-9.9 μU/mL, with IGI 0.25, 0.14, 0.10, respectively.
Discussion and conclusion: Newly-proposed IGI-carbo70 was investigated, and there were several correlations among 8 related biomarkers. These findings suggest that current results would become the fundamental data and IGIcarbo70 could be the useful way to evaluate diabetic status by usual meal with mixed nutrients.

Keywords: (IGI-carbo70) Insulinogenic index-carbohydarate 70 g; (CR) Calorie restriction; (LCD) Low carbohydrate diet; (T2DM) Type 2 diabetes mellitus; (IRI) Immunoreactive insulin

Citation: Bando H, Ebe K, Muneta T, Bando M, Yonei Y (2017) Proposal for Insulinogenic Index (IGI)-Carbo70 as Experimental Evaluation for Diabetes . J Clin Exp Endocrinol 1: 102.

Copyright: © 2017 Bando H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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