Raman Microspectroscopy Demonstrates Alterations in Human Mandibular Bone after Radiotherapy | OMICS International | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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Research Article

Raman Microspectroscopy Demonstrates Alterations in Human Mandibular Bone after Radiotherapy

Singh SP1,2, Parviainen I1, Dekker H3, Schulten EAJM3, ten Bruggenkate CM3, Bravenboer N3, Mikkonen JJ2, Turunen MJ4, Koistinen AP2 and Kullaa AM1,5,6*

1Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Yliopistonranta 1, Kuopio, Finland

2SIB Labs, University of Eastern Finland, Yliopistonranta 1, Kuopio, Finland

3Department of Oral and Maxillofacial Surgery and Oral Pathology, VU University Medical Center/Academic Centre for Dentistry Amsterdam (ACTA), Amsterdam, The Netherlands

4Department of Applied Physics, Faculty of Science and Forestry, University of Eastern Finland, Kuopio, Finland

5Research Group of Oral Health Sciences, Faculty of Medicine, University of Oulu, Oulu, Finland

6Educational Dental Clinic, Kuopio University Hospital, Kuopio, Finland

*Corresponding Author:
Arja Kullaa
Institute of Dentistry
University of Eastern Finland
Kuopio campus, Yliopistonranta 1
Kuopio, Finland
Tel: +358-44-5150452
E-mail: [email protected]/[email protected]

Received date: August 21, 2015; Accepted date: September 07, 2015; Published date: September 14, 2015

Citation: Singh SP, Parviainen I, Dekker H, Schulten EAJM, ten Bruggenkate CM, et al. (2015) Raman Microspectroscopy Demonstrates Alterations in Human Mandibular Bone after Radiotherapy. J Anal Bioanal Tech 6:276. doi:10.4172/2155-9872.1000276

Copyright: © 2015 Singh SP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Quality and alterations in the biochemical composition of bones used for dental implantation after radiotherapy in cancer patients is always a critical and debatable factor. Clinically the irradiated bone is similar to control bone. The aim of this study was to verify any compositional alterations in human mandible bone after irradiation using Raman microspectroscopy. A total of 36 bone biopsies (21-control, 4-cancer and 11-irradiated) were investigated. Data acquisition points were determined under histopathological supervision. Both mineral and matrix constituents were analyzed by computing area associated with of phosphate (958 cm-1), carbonate (1070 cm-1) and matrix (amide I) bands. Unpaired Student’s t-test was employed to measure level of significance. Absolute mineral contents (phosphate and carbonate) were highest in cancerous specimens. Spectral profile and band-intensity calculations suggest proximity of irradiated specimens with control specimens. Significant differences in both matrix and mineral contents were observed when control/irradiated samples were compared against cancerous specimens. However, no significant differences were observed between control and irradiated groups. Irradiated bone is similar to control and cause of implant loss could be related to osteocytes of the surrounding tissue.

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