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Rapid Simultaneous Determination of Sumatriptan Succinate and Naproxen Sodium in Combined Tablets by Validated Ultra Performance Liquid Chromatographic Method | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Research Article

Rapid Simultaneous Determination of Sumatriptan Succinate and Naproxen Sodium in Combined Tablets by Validated Ultra Performance Liquid Chromatographic Method

Yarram Ramakoti Reddy1*, Kakumani Kishore Kumar1, MRP Reddy2 and K. Mukkanti1

1Centre for Chemical Science and Technology, Institute of science and Technology, Jawaharlal Nehru Technological University, Hyderabad 500085, India

2Centre for Meterials for Electronics Technology IDA, HCL post, Cherlapally, Hyderabad, India

*Corresponding Author:
Dr. Yarram Ramakoti Reddy
Centre for Chemical Science and Technology
Institute of science and Technology
Jawaharlal Nehru Technological University, Hyderabad 500085, India
Tel: (+)91 9849392039
E-mail: [email protected], [email protected]

Received date: April 18, 2011; Accepted date: May 28, 2011; Published date: May 30, 2011

Citation: Reddy YR, Kumar KK, Reddy MRP, Mukkanti K (2011) Rapid Simultaneous Determination of Sumatriptan Succinate and Naproxen Sodium in Combined Tablets by Validated Ultra Performance Liquid Chromatographic Method. J Anal Bioanal Tech 2:121. doi: 10.4172/2155-9872.1000121

Copyright: © 2011 Reddy YR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A stability- indicating ultra perfomance liquid chromatography (UPLC) method was developed for the simultaneous determination of sumatriptan succinate and Naproxen sodium in pharmaceutical dosage forms. The chromatographic separation was achieved on C18, 50 mm × 4.8 mm, 1.8-μm particle size column. The mobile phase contains a mixture of 0.2% ortho phosphoric acid and acetonitrile as the mobile phase in gradient elution technique. The retention time of Sumatriptan and Naproxen was found to be 1.7 and 2.7 min respectively. The total runtime was 5 min within which two active compounds and degradation products were separated. This method allows the determination of 850-2565 μg mL -1 of sumatriptan succinate and 5000-15000 μg mL -1 of Naproxen sodium. The flow rate was 1.0 mL min -1 and the detection wavelength was 225 nm. The limit of detection (LOD) for sumatriptan succinate and Naproxen sodium was 1.9 and 1.5 μg mL -1 , respectively. The limit of quantification (LOQ) for sumatriptan succinate and Naproxen sodium was 6.3 and 4.8 μg mL -1 , respectively. This method was validated for accuracy, precision, linearity and robustness. sumatriptan succinate and Naproxen sodium were subjected to different ICH prescribed stress conditions of oxidative, acid, base, hydrolytic, thermal and photolytic degradation and the method was also found to be stability indicating.

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