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ISSN: 2155-6105

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Research Article

Relationship between Crystal Form of Cefoperazone Sodium and Its Stability

Jing Xue1, Chang-qin Hu1*, Li-hong Yang2, Rui-ping Wei3, Jian-wen Li3 and Bing-zhang Hou3

1National Institutes for Food and Drug Control, Beijing, 100050, P.R. China

2Heilongjiang Institute for Food and Drug Control, Heilongjiang, 150001, P.R. China

3Shanghai Asia Pioneer Pharmaceutical Co., Ltd., Shanghai, 201203, P.R. China

*Corresponding Author:
Dr. Chang-qin Hu
National Institutes for Food and Drug Control
No. 2 Tiantanxili Chongwen District, Beijing, 100050, P.R. China
Tel: +8610-67095308
Fax: +8610-65115148
E-mail: [email protected]

Received February 25, 2011; Accepted October 20, 2011; Published October 24, 2011

Citation: Xue J, Chang-qin H, Li-hong Y, Rui-ping W, Jian-wen L, et al. (2011) Relationship between Crystal Form of Cefoperazone Sodium and Its Stability. J Addict Res Ther 2:116. doi:10.4172/2155-6105.1000116

Copyright: © 2011 Xue J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: The aim of this work was to study the relationship between the crystal form of Cefoperazone sodium (CPZ-Na) and its stability. Methods: To classify CPZ-Na into amorphous powder and crystalline, powder X-ray diffraction (PXRD) was used. To classify CPZ-Na crystal powder into crystal form A and B, thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used. To further classify CPZ-Na crystal form A into different subtypes, clustering of PXRD data and scanning electron microscopy (SEM) were used. To compare the stability of CPZ-Na crystal form A and B, temperature controlled PXRD and high performance liquid chromatography (HPLC) were used. Results: CPZ-Na was classified into amorphous powder and crystalline, CPZ-Na crystal powder was classified into crystal form A and B, and CPZ-Na crystal form A was further classified into different subtypes. Moreover, the stability of CPZ-Na crystal form A was higher than that of crystal form B, and different subtypes of CPZ-Na crystal form A had different stability. Conclusions: There was a close relationship between the crystal form of CPZ-Na and its stability.

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