alexa Reversal of Cognitive Decline: 100 Patients | OMICS International| Abstract

ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism

  • Case Report   
  • J Alzheimers Dis Parkinsonism 2018, Vol 8(5): 450
  • DOI: 10.4172/2161-0460.1000450

Reversal of Cognitive Decline: 100 Patients

Dale E Bredesen1*, Kenneth Sharlin2, David Jenkins3, Miki Okuno3, Wes Youngberg4, Sharon Hausman Cohen5, Anne Stefani5, Ronald L Brown6, Seth Conger6, Craig Tanio7, Ann Hathaway8, Mikhail Kogan9, David Hagedorn10, Edwin Amos11, Amylee Amos12, Nathaniel Bergman13, Carol Diamond14, Jean Lawrence15, Ilene Naomi Rusk16, Patricia Henry16 and Mary Braud16
1Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
2Sharlin Health and Neurology/Functional Medicine, Ozark, MO, USA
3NeuroHub, Sydney, Australia
4Youngberg Lifestyle Medicine Clinic, Temecula, CA, USA
5Resilient Health, Austin, TX, USA
6Carolina Healthspan Institute, Charlotte, NC, USA
7Rezilir Health, Hollywood, FL, USA
8Integrative Functional Medicine, San Rafael, CA, USA
9GW Center for Integrative Medicine, George Washington University, Washington, DC, USA
10Coastal Integrative Medicine, Jacksonville, NC, USA
11Department of Neurology, University of California, Los Angeles, Los Angeles, CA, USA
12Amos Institute, Los Angeles, CA, USA
13Center for Functional Medicine, Cleveland Clinic, Cleveland, OH, USA
14Mount Sinai Hospital, New York, NY, USA
15Lawrence Health and Wellness, Toccoa, GA, USA
16Brain and Behavior Clinic, Boulder, CO, USA
*Corresponding Author : Dale E Bredesen, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA, Tel: +014152541041, Email: [email protected]

Received Date: Oct 08, 2018 / Accepted Date: Oct 12, 2018 / Published Date: Oct 19, 2018


The first examples of reversal of cognitive decline in Alzheimer’s disease and the pre-Alzheimer’s disease conditions MCI (Mild Cognitive Impairment) and SCI (Subjective Cognitive Impairment) have recently been published. These two publications described a total of 19 patients showing sustained subjective and objective improvement in cognition, using a comprehensive, precision medicine approach that involves determining the potential contributors to the cognitive decline (e.g., activation of the innate immune system by pathogens or intestinal permeability, reduction in trophic or hormonal support, specific toxin exposure, or other contributors), using a computer-based algorithm to determine subtype and then addressing each contributor using a personalized, targeted, multi-factorial approach dubbed ReCODE for reversal of cognitive decline.

An obvious criticism of the initial studies is the small number of patients reported. Therefore, we report here 100 patients, treated by several different physicians, with documented improvement in cognition, in some cases with documentation of improvement in electrophysiology or imaging, as well. This additional report provides further support for a randomized, controlled clinical trial of the protocol and the overall approach.

Keywords: Alzheimer’s; Mild cognitive impairment; Programmatics; ReCODE; Precision medicine; Amyloid precursor protein; Synaptoblastic; Synaptoclastic

Citation: Bredesen DE, Sharlin K, Jenkins D, Okuno M, Youngberg W, et al. (2018) Reversal of Cognitive Decline: 100 Patients. J Alzheimers Dis Parkinsonism 8: 450. Doi: 10.4172/2161-0460.1000450

Copyright: © 2018 Bredesen DE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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