Rodent Model of ParkinsonÃ¢ÂÂs Disease: Unilateral or Bilateral?Zhiyuan Zheng and Wai Sang Poon*
Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Hong Kong, China
- *Corresponding Author:
- Wai Sang Poon
4/F Lui Che Wo Clinical Sciences Building
Department of Surgery, Prince of Wales Hospital
30-32 Ngan Shing Street, Shatin, Hong Kong, China
Received date: March 21, 2017; Accepted date: April 10, 2017; Published date: April 17, 2017
Citation: Zheng Z, Poon WS (2017) Rodent Model of Parkinson’s Disease: Unilateral or Bilateral? J Alzheimers Dis Parkinsonism 7:319. doi:10.4172/2161-0460.1000319
Copyright: © 2017 Zheng Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases affecting the aging population worldwide. Levodopa (L-DOPA) is the gold standard of PD therapy, which is administrated for symptomatic treatment. However, long-term application of L-DOPA leads to less effectiveness and a dose-dependent side effect of dyskinesia. Therefore, to help understand the pathogenesis and clarify potential therapeutic strategies, a great effort is made for the preclinical research on experimental PD models. Since the variety of the animal models is employed in the research work of PD, a controversy has arisen over the reproducibility of experimental models to clinical Parkinsonism. The experimental paradigms are diverse, with which partial Parkinsonism features can be induced in rodents, while others may be limited. Rodent models need to be validated for further use in pathophysiological and therapeutic investigations. This review summarizes the characteristics of the commonly used experimental PD models on rodents, including both unilateral and bilateral models, which may provide useful ideas on selection the most applicable animal model on specific aims of PD research. In conclusion, bilateral models are more consistent with the natural pathogenic process of PD, although there currently exists no model completely reproducing the clinical characteristics of human patients.