alexa

GET THE APP

Saliva as a Biomarker of Heat Shock Protein in Chronic Renal Disease | OMICS International | Abstract
ISSN: 2376-032X

JBR Journal of Interdisciplinary Medicine and Dental Science
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Saliva as a Biomarker of Heat Shock Protein in Chronic Renal Disease

Mithra N Hegde1, Nireeksha2* and Shilpa Shetty3

1Department of Conservative Dentistry and Endodontics, A. B. Shetty Memorial Institute of Dental Sciences, India

2Department of Conservative Dentistry and Endodontics, A. B. Shetty Memorial Institute of Dental Sciences, India

3Central Research Laboratory, Nitte University, India

*Corresponding Author:
Nireeksha
Post Graduate Student, Department of Conservative Dentistry and Endodontics
A. B. Shetty Memorial Institute of Dental Sciences
Mangalore, India
Tel: 9739755940
E-mail: [email protected]

Received Date: March 24, 2016; Accepted Date: April 22, 2016; Published Date: April 30, 2016

Citation: Hegde MN, Nireeksha, Shetty S (2016) Saliva as a Biomarker of Heat Shock Protein in Chronic Renal Disease. J Interdiscipl Med Dent Sci 4:195. doi: 10.4172/2376-032X.1000195

Copyright: © 2016 Hedge MN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and Objective: Heat shock protein 70 usually located in the cytoplasm, it plays an important role has a chaperone. It said to have anti- proinflammatory effect, as shown in experimental model. These play an extended role in immunity and implication in pathogenesis of systemic conditions. In chronic renal kidney disease the complexity of underlying disturbances is an ideal example for persistent multifactorial stress. The combination of uremic toxins, mediators of inflammation, oxygen species, apoptosis and renal dialysis. The role of heat shock proteins in chronic renal damage, their protective and deleterious effect is of prime importance for the future perspectives of optimizing renal therapy the aim of this study was to evaluate the circulatory and salivary heat shock protein level 70 in healthy individuals and individuals undergoing renal dialysis with chronic renal disease.

Method: 40 patients attending to the department of nephrology, K. S. Hegde Medical hospital diagnosed with chronic renal disease, undergoing renal dialysis in the age group of 35-60 yrs were included in the study. Individuals with other active infections, pregnant and lactating women’s, smokers were excluded from the study. The study was conducted among Control (n = 40) and Experimental group (n = 40). Saliva and serum samples were evaluated for Heat shock protein 70 by ELIZA Method (Enzyme -linked immunoassay for heat shock protein 70) and statistical analysis was done with independent student‘t’ test. P < 0.05 was considered to be statistically significant.

Conclusion: Salivary and circulatory Heat Shock protein 70 showed significant increase in Individuals undergoing renal dialysis .Thus, Circulatory and salivary Heat Shock Protein 70 is an efficient stress marker in chronic renal disease condition.

Keywords

Top