alexa Sickle Cell Trait, Malaria and Sensorineural Hearing Loss–A Case-Control Study from São Tomé and Príncipe | OMICS International | Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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Research Article

Sickle Cell Trait, Malaria and Sensorineural Hearing Loss–A Case-Control Study from São Tomé and Príncipe

Cristina Caroça1,2,3*, João Pereira de Lima3, Paula Campelo2, Elisabete Carolino4, Helena Caria5,6, João Paço1,2 and Susana Nunes Silva1,3

1Department of Medical Sciences, Nova Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal

2Hospital CUF Infante Santo, 34, 6º, 1350-079 Lisboa, Portugal

3Centre for Toxicogenomics and Human Health (ToxOmics), Faculty of Medical Sciences, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisboa, Portugal

4Escola Superior de Tecnologia da Saúde de Lisboa, Av. Dom João II Lote 4.69.01, 1990-096 Lisboa

5BioISI - Biosystems & Integrative Sciences Institute, Faculty of Science of the University of Lisbon, R. Ernesto de Vasconcelos, 1749-016 Lisboa, Portugal

6ESS/IPS, School of Health, Polytechnic Institute of Setúbal, Campus do IPS - Estefanilha, 2910-761 Setúbal, Portugal

*Corresponding Author:
Cristina Caroça, MD
Department of Medical Sciences Nova Medical School
Universidade Nova de Lisboa Campo Mártires
da Pátria 130 1169-056 Lisboa, Portugal
Tel: 00 351 917507165
Fax: 918902967
E-mail: [email protected]

Received date: October 30, 2016; Accepted date: November 22, 2016; Published date: November 29, 2016

Citation: Caroça C, de Lima JP, Campelo P, Carolino E, Caria H, et al. (2016) Sickle Cell Trait, Malaria and Sensorineural Hearing Loss–A Case-Control Study from São Tomé and Príncipe. Otolaryngol (Sunnyvale) 6:278. doi:10.4172/2161-119X.1000278

Copyright: © 2016 Caroça C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Hearing loss is a problem with higher incidence in South Asia, Asia Pacific and sub-Saharan Africa. In these countries there is also associated history of anemia and malaria. Objective: This study aims to identify a putative role of Beta globin mutation - sickle cell trait and HL in São Tomé and Príncipe population. Methods: A retrospective case-control study of a convenience sample was collected during Otolaryngologist Humanitarian Missions in São Tomé and Príncipe. Control group includes individuals with normal hearing in both ears, and the case group has participants presenting bilateral or unilateral HL. It was evaluated the potential risk factors and sickle cell trait with HL, as well self-report of malaria infection, consanguinity, familial history of HL. The HbS gene point mutation (Glu6Val) was determined by PCR-RFLP. Results: Our results showed a statistical significance between HL - oral language and self-report of HL. Taken altogether, our data did not reveal association between sickle cell trait and HL. However, a statistical association between HL and self-report of malaria was found. Conclusion: No association between sickle cell trait and the high prevalence of HL was found. Self-report of Malaria was found as a risk factor for the development of HL in São Tomé and Príncipe population. The multifactorial profile of HL shall not exclude the relevance of other etiologic factors than Malaria to justify the high prevalence of HL in São Tomé and Príncipe and further investigation must be applied.

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