Significance of Expression of Cancer Stem Cell Markers CD133
Received Date: Oct 12, 2018 / Accepted Date: Oct 30, 2018 / Published Date: Nov 09, 2018
Abstract
Pancreatic adenocarcinoma of ductal origin (PDAC) is considered one of the most aggressive malignancies and also one of the most chief causes of deaths related to cancer. It has a very poor prognosis and high recurrence rate. We investigated the expression of CSC markers (CD133 and nestin) in different grades of pancreatic intraepithelial neoplasms (PanINs) and PDAC and correlate the expression levels of these markers with clinicopathological data with the aid of Ki67 expression. Our findings showed that both cancer stem markers (CSC) are related to the PanINto- PDAC sequence. Both markers may contribute in proliferation index, tumor differentiation and infiltration. So they may also be useful for developing new therapeutic modalities for PDAC.
Keywords: Cancer stem cell markers; Pancreatic adenocarcinoma; Pancreatic intraepithelial neoplasms; Nestin; CD133
Citation: Alshenay A (2018) Significance of Expression of Cancer Stem Cell Markers CD133. Diagn Pathol Open 3: 146. Doi: 10.4172/2476-2024.1000146
Copyright: © 2018 Alshenay A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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