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Stability Study of Fluconazole Applying Validated Bioassay and Stability-Indicating LC Methods | OMICS International | Abstract
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Research Article

Stability Study of Fluconazole Applying Validated Bioassay and Stability-Indicating LC Methods

Josilene Chaves Ruela Corrêa1*, Camila Reichman1, Cristina Duarte Vianna-Soares2 and Hérida Regina Nunes Salgado1

1Drugs and Medicines Quality Control Laboratory, School of Pharmaceutical Sciences, University Estadual Paulista, Rodovia Araraquara-Jaú, km 1, 14801-902, Araraquara, Brazil

2Department of Pharmaceutical Products, Federal University of Minas Gerais, Av. Pres. Antônio Carlos, 6627, 31270-901, Belo Horizonte, Brazil

*Corresponding Author:
Josilene Chaves Ruela Corrêa
Drugs and Medicines Quality Control Laboratory
School of Pharmaceutical Sciences
University Estadual Paulista, Brazil
Tel: +55 16 3301 4681
E-mail: [email protected]

Received date: October 16, 2011; Accepted date: November 29, 2011; Published date: December 02, 2011

Citation: Corrêa JCR, Reichman C, Soares CDV, Salgado HRN (2011) AStability Study of Fluconazole Applying Validated Bioassay and Stability-Indicating LC Methods. J Anal Bioanal Tech 2:126. doi: 10.4172/2155-9872.1000126

Copyright: © 2011 Corrêa JCR. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Chemical degradation of drugs may result in altered therapeutic efficacy and even toxic effects. Therefore, understanding the factors that change the stability of pharmaceuticals and identifying ways to guarantee their stability are important. In this work stability-indicating Liquid Chromatographic (LC) and bioassay methods were validated and employed in the fluconazole stability studies. The correlation of sample results from both methods was evaluated. Fluconazole raw material stability was investigated in aqueous, acid (0.1 M HCl), alkaline (0.1 M NaOH) and oxidative (3% v/v H2O2) reflux for 6 hours, by LC method. Fluconazole capsules were exposed to UVC (254 nm, 66 and 180 days), climatic chamber (40°C, 75% RH, 90 days) and oven (60°C, 60 days), these samples were analyzed by LC and bioassay methods It was found that the drug is degraded (10% decrease) with arising of a possible degradation product in an oxidative medium and UVC exposure, in all the others conditions fluconazole remained chemically stable (higher than 98%) when analyzed by LC. However when the capsules stressed samples were evaluated through bioassay very low antifungal activity was found (about 30%). Fluconazole showed to be an unstable drug and it indicates that special care must be taken during the handling, storage and quality control using appropriated methods to analyze this therapeutic agent. This work suggests monitoring the fluconazole stability by bioassay and the stability-indicating LC methods.

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