International Journal of Advance Innovations, Thoughts & Ideas
Open Access

Mini Review

Structures and Biosynthesis of Enediyne Natural Products

¹Department of Biochemistry and Molecular biology, University of Louisville, School of Medicine, Louisville, KY 40202, USA

²Department of Physiology and Neurobiology, Geisel Medical School at Dartmouth, Lebanon, NH 03756, USA

³Department of Biochemistry and Molecular biology, University of Louisville, School of Medicine, Louisville, KY 40202, USA

⁴Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA

^#The first two authors contributed equally

*Corresponding Author:

Dr. Xiaolei Chen
Department of Chemistry
Dartmouth College, Hanover, NH 03755, USA
E-mail: xiaolei.chen@dartmouth.edu

Received date: June 12, 2014; Accepted date: June 25, 2014; Published date: July 02, 2014

Citation: Rui J, Fuli L, Lingbin M, Xiaolei C (2014) Structures and Biosynthesis of Enediyne Natural Products. Int J Adv Innovat Thoughts Ideas 3:157. doi:

Copyright: © 2014 Rui Ji, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and production in any medium, provided the original author and source are credited.

Enediyne natural products are important member of natural product family with strong DNA cleavage activity. This biological activity makes them excellent candidates for developing novel antibiotics and antitumor drugs. Highly unsaturated enediyne cores, sugar moieties and aromatic moieties are basic components of structures of enediyne natural products. Genes encoding enzymes responsible for enediyne natural product biosynthesis are clustered in enediyne gene clusters. Each gene cluster consists of dozens of genes that encode enzymes for biosynthesis of enediyne core, sugar moieties and aromatic moieties as well as tailing enzymes.