alexa Study on Slice-based Biosensor for Electrophysiological Propagation Measurement in Drugs Screening
ISSN: 2153-0777

Journal of Bioengineering and Bioelectronics
Open Access

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Research Article

Study on Slice-based Biosensor for Electrophysiological Propagation Measurement in Drugs Screening

Qing-mei CHEN1,2, Rong LI1, Li-dan XIAO1, Qing-jun LIU1 and Ping WANG1*
1Biosensor National Special Lab, Key Lab for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, PR China
2Department of Biomedical Engineering, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, PR China.
Corresponding Author : Dr. Ping WANG
Biosensor National Special Lab
Key Lab for Biomedical Engineering of Ministry of Education
Department of Biomedical Engineering
Zhejiang University
Hangzhou 310027, PR China
Tel: +86 571 87952832
Fax: +86 571 87951676
E-mail: [email protected]
Received June 24, 2011; Accepted August 16, 2011; Published October 14, 2011
Citation: Chen QM, LI R, Xiao LD, LIU QJ, Wang P (2011) Study on Slice-based Biosensor for Electrophysiological Propagation Measurement in Drugs Screening. J Biochip Tissue chip S1:004. doi:10.4172/2153-0777.S1-004
Copyright: © 2011 Chen QM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

In order to investigate the signal propagation of the cardiac tissue and the action of drugs, we developed a slice- based biosensor to monitor the electrophysiological activities of the cardiac tissues. At first, we analyzed the interface model of the slice-based biosensor and the electrolyte, and observed the characteristics of the slice-based biosensor with tissue over time. Then, using the slice-based biosensor we sampled the beating signals of the cardiac slices respectively in the presence of the normal Tyrode’s solution, Adrenaline Hydrochloride and Acetylcholine chloride. Further, we used statistic analysis and correlation analysis to review the propagation of beating signals and the action of drugs on propagation. Results showed that the slice-based biosensor is apt and stable enough to catch the character and tendency of signal propagation and Delay is the key to deduce the conduction tendency. Adrenaline Hydrochloride and Acetylcholine chloride respectively have excitatory and inhibiting action on Amplitude and Frequency of the beating signals, and appear dependent on dosage. Thus, slice-based biosensor offers a noninvasive and versatile method to study the cardiac beating and the electrophysiological propagation for drugs screening. It is significative to guide clinical remedy of the drugs’ acting targets in the future.

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