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Surface Immobilization of Antibacterial Quorum Sensing Inhibitors by Photochemical Activation | OMICS International| Abstract
ISSN: 2155-952X

Journal of Biotechnology & Biomaterials
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  • Research Article   
  • J Biotechnol Biomater 2016, Vol 6(3): 238
  • DOI: 10.4172/2155-952X.1000238

Surface Immobilization of Antibacterial Quorum Sensing Inhibitors by Photochemical Activation

Aditi Taunk1, Kitty Ka Kit Ho1, George Iskander1, Mark DP Willcox2 and Naresh Kumar1*
1School of Chemistry, University of New South Wales, Sydney, NSW 2052, , Australia
2School of Optometry and Vision Science, University of New South Wales, Sydney, NSW 2052, , Australia
*Corresponding Author : Naresh Kumar, School of Chemistry, The University of New South Wales, Sydney, NSW 2052, Australia, Tel: 61 2 9385 4698, Fax: 61 2 9385 6141, Email: [email protected]

Received Date: Jul 21, 2016 / Accepted Date: Jul 30, 2016 / Published Date: Aug 06, 2016

Abstract

Infection of implanted medical devices is one of the major causes of nosocomial infections. A significant proportion of the devices become colonized by bacterial biofilms, thus resulting in high morbidity and risk of mortality. This study focuses on the non-specific covalent attachment of potent quorum sensing (QS) and biofilm inhibiting compounds, furanones (FUs) and dihydropyrrol-2-ones (DHPs), onto glass surfaces by azide/nitrene chemistry. The attachment of FUs and DHPs was confirmed by X-ray photoelectron spectroscopy (XPS) and contact angle measurements. The modified surfaces were then assessed for their antibacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa using confocal laser scanning microscopy (CLSM). Both FU and DHP coated surfaces were able to significantly reduce bacterial adhesion (p<0.001) with p-bromophenyl substituted DHP giving maximum reductions of up to 93% and 71% against S. aureus and P. aeruginosa, respectively. Therefore, photoimmobilization of QS inhibitors is an effective technique to produce novel antibacterial biomaterial surfaces.

Keywords: Biomaterial, Antibacterial, Quorum sensing, Surface modification, Furanone, Dihydropyrrolone, Pseudomonas aeruginosa, Staphylococcus aureus

Citation: Taunk A, Ho KKK, Iskander G, Willcox MDP, Kumar N (2016) Surface Immobilization of Antibacterial Quorum Sensing Inhibitors by Photochemical Activation. J Biotechnol Biomater 6:238. Doi: 10.4172/2155-952X.1000238

Copyright: © 2016 Taunk A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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