Journal of Alzheimers Disease & Parkinsonism
Open Access

Review Article

Targeting Hypertension to Manage Alzheimer's Disease: Rational and Promise

Cifuentes D^1,2, Pasteur-Rousseau A^1,3, Levy BI², Merkulova-Rainon T2 and Kubis N^1,3*

¹Universite Paris Diderot, Sorbonne Paris Cite, CART, INSERM U965, F-75010 Paris, France

²Institut Vaisseaux Sang, Hopital Lariboisiere F-75010 Paris, France

³Service de Physiologie Clinique, AP-HP, Hopital Lariboisiere, F-75010 Paris, France

Corresponding Author:

Nathalie Kubis
Universite Paris Diderot, Sorbonne Paris Cite, CART
INSERM U965, Service de Physiologie Clinique
Hopital Lariboisiere 2 rue Ambroise Pare, 75010, Paris, France
Tel: (33) 1 49 95 88 08
E-mail: nathalie.kubis@aphp.fr

Received date: March 16, 2016; Accepted date: April 01, 2016; Published date: April 08, 2016

Citation: Cifuentes D, Pasteur-Rousseau A, Levy BI, Merkulova-Rainon T, Kubis N (2016) Targeting Hypertension to Manage Alzheimer’s Disease: Rational and Promise. J Alzheimers Dis Parkinsonism 6:228. doi:10.4172/2161-0460.1000228

Copyright: © 2016 Cifuentes D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Epidemiological, clinical and experimental animal studies uncover the close and complex interaction between Alzheimer’s disease and hypertension, a major risk factor for cardiovascular disease and stroke. Here we overview recent evidences on the impacts of both conditions on cerebral vasculature and discuss the ways in which hypertension may contribute to the onset and progression of Alzheimer’s disease.

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