alexa The Effects of 6and#946;-Naltrexol, a Putative Neutral Opioid Antagonist, in Opioid-Dependent Subjects: A Proof-of-Concept Trial | OMICS International| Abstract

ISSN: 2155-6105

Journal of Addiction Research & Therapy

  • Research Article   
  • J Addict Res Ther 2011, Vol 2(2): 108
  • DOI: 10.4172/2155-6105.1000108

The Effects of 6β-Naltrexol, a Putative Neutral Opioid Antagonist, in Opioid-Dependent Subjects: A Proof-of-Concept Trial

John Mendelson1*, Linghui Li1, Keith Flower1, Will Harris1, Jeremy R Coyle1, C Y Angie Chen1, Wolfgang Sadee2 and Gantt P Galloway1
1Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, , San Francisco, CA, USA
2Program in Pharmacogenomics, Department of Pharmacology, College of Medicine, The Ohio State University, Columbus OH 43210, USA
*Corresponding Author : John Mendelson MD, Addiction and Pharmacology Research Laboratory, California Pacific Medical Center Research Institute, San Francisco, CA, United States, Tel: (415)-641-3370, Fax: (415)-641-3380, Email: [email protected]

Received Date: Jan 19, 2011 / Accepted Date: Apr 14, 2011 / Published Date: Apr 20, 2011

Abstract

Potential complications of prescription opioid use include abuse and constipation. 6β-Naltrexol (6βNTX), a neutral opioid antagonist, may alleviate these complications when co-formulated with μ-opioid analgesics. In a double-blind ascending dose study, four subjects on methadone maintenance received 6βNTX (0.05, 0.15, 0.50 and 1.0 mg). 6βNTX was generally well tolerated; three of four subjects reported willingness to take higher doses. Increased gastrointestinal activity was evidenced by decreased oral-cecal transit time and prompt laxation at higher doses.

Keywords: 6-β-Naltrexol; Naltrexone; Naloxone; Opioid dependence; Opioid antagonist

Citation: Mendelson J, Li L, Flower K, Harris W, Coyle JR, et al. (2011) The Effects of 6?-Naltrexol, a Putative Neutral Opioid Antagonist, in Opioid-Dependent Subjects: A Proof-of-Concept Trial. J Addict Res Ther 2:108. Doi: 10.4172/2155-6105.1000108

Copyright: © 2010 Mendelson J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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