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The Function Profiling of TIPE2 Reveals Links to its Potential Application | OMICS International | Abstract
ISSN: 2161-0681

Journal of Clinical & Experimental Pathology
Open Access

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Review Article

The Function Profiling of TIPE2 Reveals Links to its Potential Application

Guizhong Zhang and Suxia Liu*

Department of Immunology, Shandong University School of Medicine, Ji’nan, PR China

*Corresponding Author:
Suxia Liu, Professor
Wenhua West Road, Department of Immunology
Shandong University School of Medicine, Ji’nan, PR China
Tel: 086-531-88382038
E-mail: [email protected]

Received date: February 10, 2015; Accepted date: February 28, 2015; Published date: March 10, 2015

Citation: Guizhong Zhang and Suxia Liu (2015) The Function Profiling of TIPE2 Reveals Links to its Potential Application. J Clin Exp Pathol 5:214. doi:10.4172/2161-0681.1000214

Copyright: © 2014 Zhang G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

Abstract

TIPE2, TNF-α-induced protein 8-like 2 (TNFAIP8L2), is a newly identified member of the TNFAIP8 family. Recent studies revealed that TIPE2 is a negative regulator of inflammation and carcinogenesis. TIPE2 deletion in mice causes fatal inflammation and its dysregulation in humans is associated with diseases, such as viral hepatitis, hepatocellular carcinoma, and atherosclerosis. The function profiling of TIPE2 in normal or pathological conditions indicates its potential application in immunotherapy.

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