The Genetic Polymorphisms of TERT-CLPTM1L and Lung Cancer Susceptibility: A Meta-Analysis
- *Corresponding Author:
- Jie Liu
Department of Oncology
Shandong Cancer Hospital & Institute
440 Jiyan Road, Jinan 250017, China
Tel: 86-531 67626331
E-mail: [email protected]
Received date: July 17, 2015; Accepted date: December 24, 2015; Published date: December 30, 2015
Citation: Cheng S, Wang F, Song B, Liu J (2015) The Genetic Polymorphisms of TERT-CLPTM1L and Lung Cancer Susceptibility: A Meta- Analysis. Epidemiology (sunnyvale) 5:215. doi:10.4172/2161-1165.1000215
Copyright: © 2015 Cheng S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To assessed the loci of the association between the single three polymorphisms (SNPs) (rs2736100, rs402710 and rs401681) and lung cancer risk. Methods: We performed a comprehensive meta-analysis of 19 publications with a total of 32,319 lung cancer cases and 5, 0529 controls via Medline, PubMed, Elsevier and Web of Science. We assessed the loci of the association between the single three polymorphisms (SNPs) (rs2736100, rs402710 and rs401681) and lung cancer risk using dominant model and performed subgroup analysis by cancer pathology and ethnicity. Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using review manager 5.2 package and Stata12.0 package. Results: Overall, significant associations were observed for rs2736100 and rs401681 polymorphisms of TERT-CLPTM1L with increased lung cancer risk (for rs2736100, OR=1.32, 95% CI=1.27-1.36, P<0.00001; for rs401681, OR=1.19, 95%CI=1.12-1.26, P<0.00001). When stratified by ethnicity, rs2736100 polymorphism was associated with increased risk of Asians (OR=1.42, 95% CI=1.36-1.49, P=0.06); When stratified by pathology, there was no significant associations were found between rs2736100, rs401681 and lung cancer and lung adenocarcinoma. Conclusions: TETT-CLPTM1L is a candidate susceptibility gene for lung cancer risk in Caucasian and Asian populations. Increased cancer risk was found in rs2736100CC and rs401681CC and homozygous variant genetic model.