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ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Review Article

The Holy Grail of Designer Probiotics: The Probiotics with Multiple Health Benefits

B. Singh1, G. Mal1, L. Bissi2 and F. Marotta2,3*

1Indian Veterinary Research Institute, Regional Station, Palampur-176 06, India

2Montenapoleone Medical Center (MMC)-Healthy Aging Unit by Genomics & Biotechnology, Milano, Italy

3ReGenera Research group for Aging Intervention Italy

Corresponding Author:
Prof. Francesco Marotta
MD, PhD, Montenapoleone Medical Center
(MMC)-Healthy Aging Unit by Genomics & Biotechnology, Milano, Italy
Tel: 39-02-407-7243
E-mail: mailto:[email protected]

Received Date: February 2, 2016; Accepted Date: March 15, 2016; Published Date: March 25, 2016

Citation: Singh B, Mal G, Bissi L, Marotta F (2016) The Holy Grail of Designer Probiotics; Designer Probiotics: The Probiotics with Multiple Health Benefits. J Gastrointest Dig Syst 6:415. doi:10.4172/2161-069X.1000415

Copyright: © 2016 Singh B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Alteration in gut microbiome is a major underlying causative factor of diverse inflammatory and metabolic diseases. Role of probiotics to promote perinatal health, prevention of obesity, irritable bowel syndrome are the current hot topics of research. The bioengineered probiotics with multiple immunogenic and antagonistic properties can deliver drugs, therapeutic proteins into host cells. Already the probiotics have been engineered for their stress tolerance profile, overcoming the physiochemical stresses of the host, and their applications in human nutrition and health. The aim of this article is to provide interest on mining the host microbiota for novel therapeutics and using designer probiotics as therapeutics and nutraceuticals in clinical practice. At the same time, novel high-throughput technologies such as NGS (New Generation Sequencing) allow a much more detailed and stable analysis of the microbiota than the one done by PCR so to direct industries in designing more selected mixtures and physicians to tentatively apply a more tailor-made gut eco-system interventions and rely on a reliable follow up tool.


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