The Molecule Mechanisms of Bone Metastasis in Breast CancerGuang-Xian Zhong, Zhao-Yang Wu, Xia Zhu and Jian-Hua Lin*
Department of Orthopaedics, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, P.R.China.
- *Corresponding Author:
- Dr. Jian-Hua Lin
Department of Orthopaedics, the First Affiliated Hospital of Fujian Medical University
Fuzhou 350004, PR China
Tel: +86 59187981029
E-mail: [email protected]
Received Date: October 31, 2015; Accepted Date: December 01, 2015; Published Date: December 08, 2015
Citation: Zhong GX, Wu ZY, Zhu X, Lin JH (2015) The Molecule Mechanisms of Bone Metastasis in Breast Cancer. J Orthop Oncol 1:102. doi:10.4172/2472-016X.1000102
Copyright: © 2015 Zhong GX, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Breast cancer is the second most common cancer diagnosed worldwide, affecting approximately one in eight women during their lifetime. Strategies targeting the primary tumour have markedly improved, but systemic treatments to prevent metastasis are less effective. Breast cancer frequently spreads to the skeleton and causes destructive osteolytic bone metastases. Breast cancers express chemokine receptors, integrins, cadherins, and bone-resorbing and bone-forming factors that contribute to the successful and preferential spread of tumor from breast to bone. Once breast cancer cells arrest in bone, bone is a storehouse of a variety of cytokines and growth factors and thus provides an extremely fertile environment for the cells to grow. This article reviews the specific molecule mechanism of the changes of breast cancer cells, bone marrow microenvironment and the interaction between cancer cell and microenvironment in breast cancer.