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The Potential of Statins for Buccal Delivery | OMICS International| Abstract
ISSN: 2329-9053

Journal of Molecular Pharmaceutics & Organic Process Research
Open Access

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  • Review Article   
  • J Mol Pharm Org Process Res 2014, Vol 2(1): 111
  • DOI: 10.4172/2329-9053.1000111

The Potential of Statins for Buccal Delivery

Gannu Praveen Kumar*, Geethika R, Anusha T, Syeda Jaweria and Prathyusha G
Department of industrial pharmacy and pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, , Andhra Pradesh, India
*Corresponding Author : Gannu Praveen Kumar, Department of industrial pharmacy and pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Vidyanagar, Warangal, Andhra Pradesh, India, Tel: +91-9397398024, Email: [email protected]

Received Date: Feb 24, 2014 / Accepted Date: Mar 14, 2014 / Published Date: Mar 24, 2014

Abstract

Statins minimize the endogenous synthesis of cholesterol preventing the onset and development of artherosclerosis and are therefore used as an effective treatment against primary hypercholesterolemia. Statins do exhibit antiinflammatory, vasculoprotective, and antioxidant effects. The promising delivery of statins across the buccal mucosa poses a continuing challenge as well as a great opportunity. Buccal delivery has progressed far beyond the use of traditional dosage forms with novel approaches emerging continuously. Buccal drug delivery system in which drug enters directly in systemic circulation thereby by passing the first pass effect. The buccal route has been researched for a wide variety of drugs and has gained significant attention and momentum since it offers remarkable advantages. Buccal adhesive systems offer innumerable advantages in terms of accessibility, administration and withdrawal, retentivity, enhanced bioavailability, avoid first pass effect. At the current global scenario, scientists are finding ways to develop buccal adhesive systems through various approaches to improve the bioavailability of antihyperlipidemic drugs by manipulation of the formulation strategies like inclusion of pH modifiers, enzyme inhibitors, permeation enhances. This review highlights the buccal delivery approaches of statins.

Keywords: Statins; Buccal; Absorption; Mucoadhesive; Polymers

Citation: Kumar GP, Geethika R, Anusha T, Jaweria S, Prathyusha G (2014) The Potential of Statins for Buccal Delivery. J Mol Pharm Org Process Res 2: 111. Doi: 10.4172/2329-9053.1000111

Copyright: ©2014 Kumar GP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

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