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The Rationale of Using Coffee and Melatonin as an Alternative Treatment for Alzheimer's Disease | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
Open Access

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Review Article

The Rationale of Using Coffee and Melatonin as an Alternative Treatment for Alzheimer's Disease

Adryan Perez1#, Tianchen Li2#, Stephanie Hernandez3, Renee Yilan Zhang1 and Chuanhai Cao1,4*
1University of South Florida Health Byrd’s Alzheimer’s Institute, USA
2University of South Florida Tampa FL 33620, USA
3Rice University, Houston TX 77005, USA
4University of South Florida College of Pharmacy, USA
Corresponding Author : Chuanhai Cao
Department of Pharmaceutical Sciences, College of Pharmacy
University of South Florida, Tampa, FL 33612, USA
Tel: +813-3960742
E-mail: [email protected]
Received: October 06, 2015; Accepted: January 08, 2016; Published: January 15, 2016
Citation: Perez A, Li T, Hernandez S, Zhang RY, Cao C (2016) The Rationale of Using Coffee and Melatonin as an Alternative Treatment for Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 6:205. doi:10.4172/2161-0460.1000205
Copyright: © 2016 Perez A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Alzheimer’s disease (AD) is a devastating neurodegenerative disease with no current cure. FDA approved drugs have been widely used to address symptoms of AD, but none have been successful in preventing or reversing its effects. As the prevalence of AD increases due to the increased lifespan of the population, it is becoming essential to discover new drugs or find alternative treatment approaches to overcome the potential toxicity induced by current medications. We have noted that coffee and melatonin can play a role in delaying disease onset and improving memory for AD patients. Once these independent discoveries were made, we tested the possibility of using them in combination as therapy for AD. In this review, we are going to summarize the results from various investigations testing caffeine, coffee, and melatonin and present a method for their combined use for maximum treatment efficacy against AD pathogenesis.


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