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Hindi Review Article
The Rationale of Using Coffee and Melatonin as an Alternative Treatment for Alzheimer's Disease
| Adryan Perez1#, Tianchen Li2#, Stephanie Hernandez3, Renee Yilan Zhang1 and Chuanhai Cao1,4* | |
| 1University of South Florida Health Byrd’s Alzheimer’s Institute, USA | |
| 2University of South Florida Tampa FL 33620, USA | |
| 3Rice University, Houston TX 77005, USA | |
| 4University of South Florida College of Pharmacy, USA | |
| #Co-authors | |
| Corresponding Author : | Chuanhai Cao Department of Pharmaceutical Sciences, College of Pharmacy University of South Florida, Tampa, FL 33612, USA Tel: +813-3960742 E-mail: ccao@health.usf.edu |
| Received: October 06, 2015; Accepted: January 08, 2016; Published: January 15, 2016 | |
| Citation: Perez A, Li T, Hernandez S, Zhang RY, Cao C (2016) The Rationale of Using Coffee and Melatonin as an Alternative Treatment for Alzheimer’s Disease. J Alzheimers Dis Parkinsonism 6:205. doi:10.4172/2161-0460.1000205 | |
| Copyright: © 2016 Perez A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |
| Related article at Pubmed, Scholar Google | |
Abstract
Alzheimer’s disease (AD) is a devastating neurodegenerative disease with no current cure. FDA approved drugs have been widely used to address symptoms of AD, but none have been successful in preventing or reversing its effects. As the prevalence of AD increases due to the increased lifespan of the population, it is becoming essential to discover new drugs or find alternative treatment approaches to overcome the potential toxicity induced by current medications. We have noted that coffee and melatonin can play a role in delaying disease onset and improving memory for AD patients. Once these independent discoveries were made, we tested the possibility of using them in combination as therapy for AD. In this review, we are going to summarize the results from various investigations testing caffeine, coffee, and melatonin and present a method for their combined use for maximum treatment efficacy against AD pathogenesis.
