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The Science of Toxicology: Modern Studies of Poisonous Substances | OMICS International | Abstract
ISSN: 2476-2067

Toxicology: Open Access
Open Access

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The Science of Toxicology: Modern Studies of Poisonous Substances

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© 2022  . This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 
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Abstract

The science of poison is known as toxicology. Animals, bacteria, plants, and chemicals are all sources of poison. Although, in the 1520s, Paracelsus, a lecturer at the University of Basel in Switzerland, proposed that an agent's potential to produce poisoning is reliant on the dose of that substance. The median lethal dosage (LD50) was established in 1920 on this premise. The LD50 is the dose that has been shown to kill 50% of the test animals. It is one of the first screening studies used with carcinogenic, anticarcinogenic, venomous, antivenomous, toxicogenic,
anti-toxicogenic, immunogenic, and anti-immunogenic substances. Any substance that counteracts a poison by (a) chemically eliminatingthe poison, (b) physically inhibiting absorption, or (c) physiologically opposing the poison's effects in the body after absorption is referred to as an antidote.

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