alexa The Status of Histopathology in the Diagnosis of Gastroesophageal Reflux Disease Time for Reappraisal?
ISSN: 2161-069X

Journal of Gastrointestinal & Digestive System
Open Access

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Review Article

The Status of Histopathology in the Diagnosis of Gastroesophageal Reflux Disease Time for Reappraisal?

Nora I. Schneider and Cord Langner*

Institute of Pathology, Medical University, Graz, Austria

*Corresponding Author:
Cord Langner, MD
Institute of Pathology, Medical University of Graz
Auenbruggerplatz 25
8036 Graz, Austria
Tel: +43 (0)316 385 13665
Fax: +43 (0)316 385 13432
[email protected]

Received date: November 05, 2015 Accepted date: November 07, 2015, Published date: November 14, 2015

Citation: Schneider NI, Langner C (2015) The Status of Histopathology in the Diagnosis of Gastroesophageal Reflux Disease – Time for Reappraisal?. J Gastrointest Dig Syst 5:355. doi:10.4172/2161-069X.1000355

Copyright: © 2015 Schneider NI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The histological diagnosis of gastroesophageal reflux disease is generally believed to be a tool of limited value. Recent data, however, indicate that histology may be useful for the management of patients with non-erosive reflux disease, who account for up to 60% of all patients with reflux symptoms. Early diagnosis of gastroesophageal reflux disease is crucial because chronic reflux esophagitis is a key risk factor for the development of Barrett´s esophagus, which predisposes to esophageal adenocarcinoma. Histologically, reflux esophagitis is characterized by basal cell hyperplasia, papillary elongation, dilation of intercellular spaces, and inflammatory infiltration. These reflux-induced changes of the squamous epithelium are mainly related to the diagnosis of acute and/or active reflux. The chronic consequences of gastroesophageal reflux disease are mainly characterized by metaplatic mucosal replacement. The origin and significance of cardiac mucosa at the gastroesophageal junction are still controversial However, evidence is accumulating that injury and repair related to gastroesophageal reflux disease contribute to its development and/or expansion. Multilayered epithelium, defined as hybrid epithelium with characteristics of both squamous and columnar epithelium has been identified as a new sensitive marker of gastroesophageal reflux disease. This epithelium may be the precursor of metaplastic cardiac mucosa, and ultimately Barrett’s esophagus.


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