alexa The Use of SHED in Cellular Therapy and Disease Modeling
ISSN: 2376-032X

JBR Journal of Interdisciplinary Medicine and Dental Science
Open Access

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Research Article

The Use of SHED in Cellular Therapy and Disease Modeling

Evangelinellis MM1,3, Pignatari GC1,3, Beltrao CFB2 and Beltrao-Braga PCB1,3,4*

1Stem Cell Lab, Surgery Department, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil

2Paulista Association of Dental Surgeons, Sao Paulo, Brazil.

3Center for Cellular and Molecular Studies and Therapy (NETCEM), Sao Paulo, Brazil

4Obstetrics Department, School of Arts, Sciences and Humanities, University of Sao Paulo, Sao Paulo, Brazil.

Corresponding Author:
Beltrao-Braga PCB
Stem Cell Lab
Surgery Department
School of Veterinary Medicine
University of Sao Paulo, Sao Paulo, Brazil
Tel: 3091-7690
E-mail: [email protected]

Received date: February 8, 2014; Accepted date: August 4, 2014; Published date: August 11, 2014

Citation: Evangelinellis MM, Pignatari GC, Beltrao CFB, Beltrao-Braga PCB (2014) The Use of SHED in Cellular Therapy and Disease Modeling. J Interdiscipl Med Dent Sci 2:143 doi:10.4172/2376-032X.1000143

Copyright: © 2014 Evangelinellis, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



During the last decade, stem cells emerged as a powerful instrument for regenerative medicine. Stem cells have the essential ability to renewal and differentiate into other cell lineages. Besides the polemic about the use of embryonic stem cells, adult stem cells represent a valid alternative avoiding ethical concerns. Different from others adult stem cells, which involved invasive procedures to be obtained, dental pulp represent a useful source of stem cells, with easy accesses. Here we focused on stem cells from human exfoliated deciduous teeth and their main characteristics, uses in regenerative medicine, immunomodulatory proprieties and as a cell source for modeling disease.


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