alexa Unique Raman Spectroscopic Fingerprints of B-Cell Non-Hodgkin Lymphoma: Implications for Diagnosis, Prognosis and New Therapies | OMICS International| Abstract

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  • Research Article   
  • J Biol Med Sci 2018, Vol 2(1): 105

Unique Raman Spectroscopic Fingerprints of B-Cell Non-Hodgkin Lymphoma: Implications for Diagnosis, Prognosis and New Therapies

Shiramizu B1,2*, Oda R1,3, Kamada N1,2, Garcia MA1, Shieh T1, Maeda TA4, Choi SY5, Lim E5 and Misra A4
1Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, , Hawaii, USA
2Department of Paediatrics, John A. Burns School of Medicine, , Hawaii, USA
3Department of Molecular Biosciences and Bioengineering, John A. Burns School of Medicine, , Hawaii, USA
4Hawaii Institute of Geophysics and Planetology, University of Hawaii, Hawaii, USA
5Biostatistics Core, Department of Complementary and Integrative Medicine, John A. Burns School of Medicine, University of Hawaii, Hawaii, USA
*Corresponding Author : Shiramizu B, Department of Tropical Medicine, Medical Microbiology, and Pharmacology, John A. Burns School of Medicine, 651 Ilalo Street, BSB 325AA, Honolulu, HI 96822, Hawaii, USA, Tel: +808-692-1677, Email: [email protected]

Received Date: Dec 29, 2017 / Accepted Date: Jan 17, 2018 / Published Date: Jan 18, 2018

Abstract

Objective: Raman spectroscopy is a non-invasive laser-based technique that identifies molecular chemical composition of tissues and cells. The objective of the work was to demonstrate that unique Raman spectroscopic fingerprints of B-cell non-Hodgkin lymphoma cells could be distinguished from normal B-cells.
Methods: Normal B-cells and B-cell non-Hodgkin lymphoma cells were mounted on aluminum slides and analyzed by Raman spectroscopy using Asymmetric Least Squares and Principal Component Analysis.
Results: Clustering by Principal Component Analysis differentiated normal B-cells from B-cell non-Hodgkin lymphoma cells as well as between the different B-cell non-Hodgkin lymphoma cell types.
Conclusions: Raman spectroscopy technology provided a different paradigm in analyzing tumor cells which could be used for diagnosis as well as contribute new information on unique characteristics of cancer cells to understand pathogenesis and potential novel treatments.

Keywords: Raman spectroscopy; Non-Hodgkin lymphoma; Lymphoma; B-cell lymphoma; Pediatric cancer

Citation: Shiramizu B, Oda R, Kamada N, Garcia MA, Shieh T, et al. (2018) Unique Raman Spectroscopic Fingerprints of B-Cell Non-Hodgkin Lymphoma: Implications for Diagnosis, Prognosis and New Therapies. J Biol Med Sci 2: 105.

Copyright: © 2018 Shiramizu B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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