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Hindi Research Article
Urinary Excretion and Renal Clearance of Allopurinol in Female Gout Patients
Bilal Ahmed*, Imtiaz SohailTahira Iqbal, Abdual Ghaffar and Bushra Munir
Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad, Punjab, Pakistan.
- *Corresponding Author:
- Bilal Ahmed
Department of Chemistry and Biochemistry, University of Agriculture
Faisalabad, Punjab, Pakistan
Tel: +923153133532
E-mail: bilalahmed814@gmail.com
Received date: February 01, 2014; Accepted date: April 30, 2015; Published date: May 07, 2015
Citation: Ahmed B, Iqbal IS, Ghaffar A, Munir B (2015) Urinary Excretion and Renal Clearance of Allopurinol in Female Gout Patients. J Anal Bioanal Tech 6:243. doi: 10.4172/2155-9872.1000243
Copyright: © 2015 Ahmed B. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Drugs are excreted from the human body either unchanged or as metabolite. Gout is treated with allopurinol drug which lowers uric acid level in humans. Xanthine oxidase activity is inhibited with allopurinol which converts hypo-Xanthine and xanthine into uric acid. In case of kidney impairment monitoring of allopurinol drug metabolism was important option for optimization of allopurinol. Allopurinol level was measured in human serum and urine of gout patients after oral intake of allopurinol by using HPLC (high performance liquid chromatography). In female gout patients (n=10) allopurinol was measured in blood and urine samples at 254 nm after taking 300 mg drug. Serum uric acid level, renal function test (RFTs) and urine complete examination was checked before and after oral administration of allopurinol. Statistically results were analyzed and explained.
