Utilizing Dehydrated Human Amnion/Chorion Membrane Allograft in Transcanal Tympanoplasty | OMICS International| Abstract
ISSN: 2161-119X

Otolaryngology: Open Access
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  • Research Article   
  • Otolaryngology 2014, Vol 4(2): 161
  • DOI: 10.4172/2161-119X.1000161

Utilizing Dehydrated Human Amnion/Chorion Membrane Allograft in Transcanal Tympanoplasty

Griffith S Hsu*
DuPage Medical Group, Department of Otolaryngology and Head and Neck Surgery, , Illinois, USA
*Corresponding Author : Griffith S Hsu, DuPage Medical Group, 430 Pennsylvania Avenue, Suite 330, Glen Ellyn, IL 60137, USA, Tel: 6305457576, Fax: 6305457839, Email: [email protected]

Received Date: Jan 23, 2014 / Accepted Date: Feb 22, 2014 / Published Date: Mar 02, 2014


Objective: To evaluate the utility and effectiveness of dehydrated Human Amnion/Chorion Membrane (dHACM) in transcanal tympanoplasty.

Patients: A retrospective analysis of 14 patients (8 adults and 4 children) with stable tympanic membrane perforations for greater than 6 months.

Intervention: Transcanal tympanoplasty performed by a single surgeon utilizing a dHACM allograft.

Main outcome measures: Operative time, pain, graft success and audiologic improvement.

Results: At the 6 week post-operative visit a decrease in perforation size was noted in 8 patients (57.1%) and complete closure of the perforation occurred in 6 (42.9%). For patients without tympanosclerosis (n=10) complete closure was achieved in 5 patients (50%) and complete or partial success in 7 patients (70%). Mean air bone gap decreased from a pre-operative measurement of 23.0 ± 10.1 dB to 16.8 ± 7.4 dB at 6 weeks after tympanoplasty. The technique was well tolerated. Using the transcanal method and dehydrated amnion/chorion membrane allograft, the mean operative time was 13.3 ± 0.10 minutes.

Conclusions: Commercially available dHACM appears to be a safe, viable graft material for transcanal tympanoplasty.

Keywords: Allograft, Amniotic membrane, Tympanoplasty

Citation: Hsu GS (2014) Utilizing Dehydrated Human Amnion/Chorion Membrane Allograft in Transcanal Tympanoplasty. Otolaryngology 4:161. Doi: 10.4172/2161-119X.1000161

Copyright: © 2014 Hsu GS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.