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Vegetable Oil-derived andlsquo; Hydroxynonenal andrsquo; Causes Diverse Cell Death Possibly Leading to Alzheimer andrsquo;s and Related Lifestyle Diseases | OMICS International | Abstract
ISSN: 2161-0460

Journal of Alzheimers Disease & Parkinsonism
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Vegetable Oil-derived ‘ Hydroxynonenal ’ Causes Diverse Cell Death Possibly Leading to Alzheimer ’s and Related Lifestyle Diseases

Tetsumori Yamashima1,2*, Piyakarn Boontem2, Hiroki Shimizu2,4, Tsuguhito Ota3, Mitsuru Kikuchi1, Tatsuya Yamashita2,4, Eishiro Mizukoshi4 and Shuichi Kaneko3
1Departments of Psychiatry and Behavioural Science, Kanazawa University Graduate School of Medical Science, Japan
2Department of Cell Metabolism and Nutrition, Kanazawa University Graduate School of Medical Science, Japan
3Department of Medicine, Asahikawa Medical University, Japan
4Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Japan
*Corresponding Author: Tetsumori Yamashima, Departments of Psychiatry and Behavioural Science, Kanazawa University Graduate School of Medical Science, Japan, Tel: +81(90)2129-1429, Fax: +81(76)247-1338, Email: [email protected]

Received Date: Oct 26, 2019 / Accepted Date: Jan 01, 2020 / Published Date: Jan 08, 2020

Citation: Yamashima T, Boontem P, Shimizu H, Ota T, Kikuchi M, et al. (2020) Vegetable Oil-derived ‘Hydroxynonenal’ Causes Diverse Cell Death Possibly Leading to Alzheimer’s and Related Lifestyle Diseases. J Alzheimers Dis Parkinsonism 10: 483.

Copyright: © 2020 Yamashima T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Objective: The real culprit of Alzheimer’s disease remains unelucidated for more than a century. Since Alzheimer’s disease is often associated with lifestyle diseases such as type 2 diabetes, there should be a common causative factor. To elucidate this, we focused on ‘Hydroxynonenal’ that is generated during deep frying of ω-6 Polyunsaturated Fatty Acids (PUFAs).

Methods: Monkeys after consecutive injections of the synthetic Hydroxynonenal were histologically studied to determine, whether it can induce cell degeneration/death in the brain, liver and pancreas.

Results: In all of the five monkeys injected, hippocampal neurons, hepatocytes and β cells after Hydroxynonenal injections revealed similar microcystic degeneration and scattered cell death by light microscopy. By electron microscopy, degenerating cells generally showed lysosomal permeabilization or rupture, electron-luscent cytoplasm, nuclear dissolution, membrane disruption, mitochondrial injury and accumulation of autophagosomes containing cell debris. The number of vivid lysosomes were remarkably decreased, compared to the controls.

Conclusion: Targeting ‘Hydroxynonenal’ would help elucidate the pathogenesis of not only Alzheimer’s disease but also related lifestyle diseases. Since ω-6 PUFAs can induce both GPR40 activation leading to calpain activation and intrinsic Hydroxynonenal generation leading to Hsp70.1 carbonylation, calpain-mediated cleavage of carbonylated Hsp70.1 was thought to disturb lysosomal membrane integrity to induce programmed cell death.


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