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Wnt Signaling and Histological Characteristics of Odontogenic Tumors | OMICS International| Abstract
ISSN: 2476-2024

Diagnostic Pathology: Open Access
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  • Short Communication   
  • Diagn Pathol Open 5: 160,
  • DOI: 10.4172/2476-2024.1000160

Wnt Signaling and Histological Characteristics of Odontogenic Tumors

Keisuke Nakano1*, Kiyofumi Takabatake1, Hotaka Kawai1, Saori Yoshida1, Hatsuhiko Maeda2, Toshiyuki Kawakami3 and Hitoshi Nagatsuka1
1Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan
2Department of Oral Pathology, School of Dentistry, Aichi Gakuin University, Nagoya 464-8650, Japan
3Hard Tissue Pathology Unit, Matsumoto Dental University Graduate School of Oral Medicine, Shiojiri 399-0781, Japan
*Corresponding Author : Keisuke Nakano, Department of Oral Pathology and Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan, Tel: (+81) 86-235-6651, Email: [email protected]

Received Date: Dec 30, 2019 / Accepted Date: Jan 14, 2020 / Published Date: Jan 21, 2020

Abstract

We examined Notch signaling in oral tumors; most of our reported findings are based on immunohistochemical studies of Notch expression in odontogenic tumors. In our investigation, we suggested that Notch signaling is involved in cell differentiation and epithelial-mesenchymal interaction in odontogenic tumors. In addition, Jagged is strongly expressed as a ligand of Notch in odontogenic tumors, and Jagged-Notch signaling may play an important role in odontogenic tumorigenesis. Wnt is expressed during tooth development and may be involved in odontogenic tumor cell differentiation and epithelial-mesenchymal interaction. Interestingly, Wnt and Notch expression sites are similar in odontogenic tumors, suggesting that Notch and Wnt signals cooperatively affect tumor formation.

Keywords: Wnt; Notch; Ameloblastoma; Ameloblastic fibroma; Odontogenic myxoma

Citation: Nakano K, Takabatake K, Kawai H, Yoshida S, Maeda H, et al. (2020) Wnt Signaling and Histological Characteristics of Odontogenic Tumors. Diagn Pathol Open 5: 160. Doi: 10.4172/2476-2024.1000160

Copyright: © 2020 Nakano K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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