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Dr. David Borchelt has been with the University of Florida since April of 2005 after 13 years on the faculty of Johns Hopkins University School of Medicine. Dr. Borchelt was recruited to the McKnight Brain Institute of UF to direct research in Alzheimer’s disease that has been generously funded by an endowment from SantaFe HealthCare (a division of AvMed, Inc.).He has authored, or co-authored, more than 100 research papers focusing on human neurodegenerative disorders. Dr. Borchelt received his Ph.D. from the University of Kentucky in 1986 where he studied the viruses that are similar to the virus that causes AIDS. After receiving his doctorate, Dr. Borchelt worked as a post-doctoral fellow with Dr. Stanley Prusiner at the University of California in San Francisco. In 1999 Dr. Prusiner won the Nobel Prize in Medicine for his work on infectious proteins that cause Mad Cow disease, Cruetzfeldt-Jakob disease, and other neurodegenerative diseases of animals and humans. The prion hypothesis is built upon the notion that a brain protein can acquire a conformation (a 3-dimensional shape) that then serves as a template to replicate the conformation; essentially transmitting the conformation from one protein to the next. During his time with Dr. Prusiner, Dr. Borchelt produced some of the seminal work on prion protein that supported this hypothesis. From this work, Dr. Borchelt he began to realize that most human neurodegenerative diseases, including amyotrophic lateral sclerosis, Huntington’s disease, and Alzheimer’s disease, share similarities with prion disease in that the symptoms and pathology are caused by the accumulation of proteins in altered conformations.
Transgenic Mice, Alzheimer's Disease, Neurodegeneration, Neurobiology, Neuroscience, Neurobiology and Brain Physiology, Molecular Biology, Genetics, Neurodegenerative Diseases, Transgenics
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