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Dr. Jin-ichi Ito Biochemistry, Cell Biology and Metabolism, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Life Science , Department, Nagoya City University Institute of Natural Science, Nagoya Department of Applied Biological Chemistry, Graduate School of, Agriculture and Life Science, The University of Tokyo, Japan. This work was supported by a Longevity Science Research Grant and a Grant for Research on Brain Science Project, from The Ministry of Health, Welfare and Labour of Japan, and Grants-in-aid from The Ministry of Science, Education, Culture and Technology of Japan.