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Dr. Mark H Sundman Research Fellow at Duke University Medical Center: Brain Imaging and Analysis Center He has extended his valuable services and has been a recipient of many award and grants. Currently, he is working as an Research Assistant for Harvard Medical School: Center for Regenerative Medicine. He is Working in the Brain Imaging and Analysis Center as the clinical research coordinator for a neuroimaging study investigating the structural and functional connectivity of the brain in Parkinson's disease (PD) patients. The two primary imaging modalities used in our study are resting state function MRI and diffusion tensor imaging (DTI). Our research is employing magnetic resonance imaging (MRI) as a means of investigating the underlying neural mechanisms of comorbidity in PD, including motor symptoms, depression, and cognitive decline. Specifically, through measuring the inter-subject correlation between 1) MRI based neuronal connectivity measures and 2) neuropsychological and motor function assessments, we aim to identify the neuronal networks that are best correlated with each of the co-existing disease phenotypes of PD. We developed a phenotype-based connectivity analysis (PBCA) to characterize the associations among a) ICN patterns; b) major disease phenotypes (e.g., motor function decline, cognitive decline and depression); and c) the progression of Parkinson’s disease. This new technique will allow the assessment of mechanistic connection, at the level of neuronal network, between multiple coexisting phenotypes of neurological diseases.
Review Article: J Alzheimers Dis Parkinsonism 2014, 4:137
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