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Professor Dr. Nibaldo C. Inestrosa, is currently the Director of a Basal Center of Excellence in Science and Technology from the Chilean Government (CONICYT), particularly, in the Centre for Aging and Regeneration (CARE), he is Full Professor from the Catholic University of Chile, at the Faculty of Biological Sciences, where he run the Molecular Neurobiology Laboratory. In 2008, he was awarded the National Award in Natural Sciences for a life-time achievement in Science. Dr. Inestrosa, has been interested in the Chemical Synaptic Neurotransmission, since the time he was trained by Professor J. V. Luco, on the trophic function of neurons. After obtaining his PhD in Cell Biology, he carried out postdoctoral training at the Neuroscience Division of the University of California San Francisco, working with Zach W. Hall and Louis F. Reichardt. Initially he worked on the interaction of acetylcholinesterase (AChE) to the synaptic basal lamina of the NMJ and first purified the mammalian brain enzyme, eventually he moves to study the interaction between AChE and the amyloid-beta peptide of the Alzheimer brain. In 2000 he proposed that the canonical Wnt signaling function was loss in Alzheimer"s disease, and eventually he established that the Wnt signaling pathway plays a key role in the regulation and differentiation of the pre- and postsynaptic regions of chemical synapses. More recently, he expanded his interests into the relationship between Wnt signaling and learning and memory, as well as in the interation of the Metabolic Syndrome and Cognition. Finally, in a more biotechnological vein he identified natural products that improve cognition and may be useful for the treatment of neurodegenerative diseases.
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