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Dr. Sepideh Shokouhi is Assistant Professor, Radiology and Radiological Sciences and Vanderbilt University Institute of Imaging Science USA. My research involves the development and application of computational methods (classification and estimation) in imaging with different modalities, such as PET, SPECT and MRI. In particular, I am interested in vivo imaging of Alzheimer's disease in both human and transgenic mouse models of AD.
My current research is focused on developing novel image analysis methods for positron emission tomography (PET) to monitor abnormal changes in functional and pathological hallmarks of Alzheimer's disease (AD). It is know that abnormal amyloid accumulation and neurodegeneration occur years or decades before the onset of clinical symptoms. I am particularly interested in developing PET methods for preclinical AD where individuals are classified as cognitively normal by having none or very little cognitive alterations but do not meet the criteria for mild cognitive impairment (MCI). A major challenge of current preclinical AD research, is to construct models of disease progression that estimate the biomarker dynamics directly from real-world experimental data. We are developing image analysis techniques to determine time trajectories for Aβ-PET and FDG-PET and to predict the subject's risk for developing decline in cognition and clinical conversion to MCI.