alexa Anil Middha | OMICS International
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
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Anil Middha


Identification and Reduction of Matrix Effects Caused by Solutol Hs15 in Bioanalysis Using Liquid Chromatography/Tandem Mass Spectrometry

Ion suppression effect of dosing vehicle excipient Solutol HS15 (SHS15) on the accuracy of liquid chromatography/ tandem mass spectrometry (LC-MS/MS) measurements was studied. Ion supression cause significant errors in accuracy of the measured concentrations of test compounds, thereby invalidating the assessment of pharmacokinetic results. Using SH... Read More»

Vijaya Bhaskar V, Anil Middha, Sudhir Tiwari and Savithiri Shivakumar

Research Article: J Anal Bioanal Tech 2013, 4:166

DOI: 10.4172/2155-9872.1000166

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article