ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

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Savithiri Shivakumar

India
Publications

Identification and Reduction of Matrix Effects Caused by Cremophor EL in Bioanalysis Using Liquid Chromatography/Tandem Mass Spectrometry

Ion suppression effect of dosing vehicle excipient Cremophor EL (CrEL) on the accuracy of liquid chromatography/ tandem mass spectrometry (LC-MS/MS) measurements was studied. Ion suppression cause significant errors in accuracy of the measured concentrations of test compounds, thereby invalidating the assessment of pharmacokinetic results. Using Cr... Read More»

Vijaya Bhaskar V, Anil Middha, Sudhir Tiwari and Savithiri Shivakumar

Research Article: J Anal Bioanal Tech 2013, 4:167

DOI: 10.4172/2155-9872.1000167

Abstract Peer-reviewed Full Article Peer-reviewed Article PDF Mobile Full Article

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