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Toshihiro Nakajima is Professor in Institute of Medical Science at Tokyo Medical University and guest professor in Institute of Medical Science at St. Marianna University School of Medicine. He worked as Vice-director in Institute of Medical Science at St. Marianna University School of Medicine from April, 2005- March, 2008. He was Head of department in Department of Genome Science, Institute of Medical Science at St. Marianna University School of Medicine from 2001- 2008.
Rheumatic disorders including fibromyalgia are known to be one of the representative chronic inflammatory diseases. In the point of view, I discovered the gene which is overexpressing rheumatoid synovium and coined that as Synoviolin. Synoviolin has been verifying its critical roles in arthritis, inflammatory cytokine-signaling and fibrosis. Recently, a gene knockout strategy was used in post-neonatal mice to delete Syvniolin and its deficiency resulted in weight loss and lower accumulation of white adipose tissue in otherwise wild-type animals as well as in genetically obese (ob/ob and db/db) and adipose tissue-specific knockout mice as compared to control animals. SYVN1 interacted with and ubiquitinated the thermogenic coactivator peroxisome proliferator activated receptor coactivator (PGC)-1β and Syvn1 mutants showed upregulation of PGC-1β target genes and increase in mitochondrion number, respiration, ,and basal energy expenditure in adipose tissue relative to control animals. Overall, we would like to utilize Synoviolin function to develop new therapeutic strategy for chronic inflammation.
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