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Received date: March 25, 2016; Accepted date: June 23, 2016; Published date: June 26, 2016
Citation: Zulli C, Alberghina N, Grande G, Manno M, Bonetti LR, et al. (2016) Retroperitoneal Schwannoma: When EUS-Guided FNA can Avoid Surgery. J Gastrointest Dig Syst 6:443. doi:10.4172/2161-069X.1000443
Copyright: © 2016 Zulli C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.
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Schwannomas are rare benign tumor that arises from peripheral or cranial nerve. Commonly, they occur into the head or neck and rarely into the retroperitoneum or pancreas. Usually they are asymptomatic tumor, discovered incidentally. Final diagnosis is generally confirmed after surgical intervention. The possibility to reach the lesion by EUS and to perform FNA can avoid invasive procedures. Here we discuss a rare case of retroperitoneal schwannoma diagnosed by Endoscopic ultrasound (EUS) guided Fine needle aspiration (FNA).
Schwannoma; Retroperitoneal tumor; Neurilemmoma; EUS-FNA
Schwannomas are rare benign tumor that arises from peripheral or cranial nerve. Commonly, they occur into the head or neck and rarely into the retroperitoneum or pancreas . Usually they are asymptomatic tumor, discovered incidentally . Final diagnosis is generally confirmed after surgical intervention. The possibility to reach the lesion by EUS and to perform FNA can avoid surgical diagnostic procedures . Actually, a surgical approach can be considered only with a therapeutic purpose, in case of presence of large symptomatic masses.
A 80 years-old woman referred to our unit to perform EUS-guided FNA of a retroperitoneal mass, discovered during follow-up abdominal US for HCV-related hepatitis. CT scan confirmed the presence of a 35 × 28 mm solid, ovoid, dis-homogeneous lesion located dorsally between the left side of abdominal aorta, left renal vein and the ascending part of duodenum (Figure 1). The patient was asymptomatic, and neoplastic markers were negative. She underwent a EUS (GF-UCT 180; Olympus Co., Japan) under deep sedation, revealing a dis-homogeneous, hypo-echoic, well-bordered, 40 × 28 mm diameter mass, located between the dorsal part of duodenum and the head of the pancreas. A EUS-FNA was performed using a 22 Gauge needle, through the duodenal wall, with the no-stylet no-suction technique (Figure 2). Histological findings included fragments of tissue composed by spindle cells showing a specific immunoreactivity to S-100; DOG1 and CD117 stains were both negative (Figure 3). Final diagnosis was a schwannoma and patient was referred to a radiological follow-up.
Schwannomas, also named neurilemmoma, are rare, benign tumors originating from Schwann cells. Retroperitoneal location is uncommon (1-3% of all Schwannomas and almost 1% of all retroperitoneal tumors). The diagnosis can be delayed due its location, so it could appear as a giant mass . Radiological findings are not pathognomonic and tissue sampling is necessary for a final diagnosis . However, definitive diagnostic result is generally obtained by surgery. Our experience suggests that EUS-guided FNA represents a reliable alternative for a noninvasive diagnosis of retroperitoneal mass . Surgery is mandatory only in case of symptomatic masses causing abdominal discomfort or pain.
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