alexa A Concise Study of Organic Volatile Impurities in Ten Different Marketed Formulations by [GC/HS-FID/MS] Gas Chromatography Technique
ISSN: 2155-9872

Journal of Analytical & Bioanalytical Techniques
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

A Concise Study of Organic Volatile Impurities in Ten Different Marketed Formulations by [GC/HS-FID/MS] Gas Chromatography Technique

Gnana Raja M1*, Geetha G2 and Sankaranarayanan A1

1Manager, Analytical research and development, KMS Health center, Chennai, India

2Professor, PSG College of Pharmacy, Coimbatore, India

*Corresponding Author:
Gnana Raja M
Manager, Analytical research and development
KMS Health Center, Padi, Chennai, Tamil Nadu, India
Tel: +917708901162
E-mail: [email protected]

Received date: July 22, 2014; Accepted date: August 25, 2014; Published date: August 29, 2014

Citation: Gnana Raja M, Geetha G, Sankaranarayanan A (2014) A Concise Study of Organic Volatile Impurities in Ten Different Marketed Formulations by [GC/HS-FID/MS] Gas Chromatography Technique. J Anal Bioanal Tech 5:202 doi: 10.4172/2155-9872.1000202

Copyright: © 2014 Gnana Raja M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Organic solvents such as Methanol, Isopropyl alcohol and Dichloromethane frequently used in sustained release or controlled release dosage form in pharmaceutical industry for coating. The good choice of solvent for coating of modified release dosage form is Methanol, Isopropyl alcohol and Dichloromethane. A selective Gas Chromatographic GC/HS-FID method has been developed and validated as per ICH guidelines for residual solvent quantification and confirmed the mass number by GC/HS-MS method. The separation was carried out on DB 624 column (30 m, 0.53 mm, [ID] 0.25 mm coating thickness), using Perkin Elmer/Clarus 500 GC/MS, with nitrogen as carrier gas in the split mode by head space injection method. The method described is simple, sensitive, rugged, reliable and reproducible for the quantization of Isopropyl alcohol, methanol and Dichloromethane at residual level in marketed modified release dosage form. In this paper completely demonstrated the method of quantification of residual solvents by GC/HS/FID and confirming by GC/HS/MS of the residual solvents present in 10 different marketed products availed in southern part of India. The enteric coated product has been selected and experiment was performed.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version