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A Randomized Double-Blind Pilot Trial of Gabapentin versus Placebo to Relieve Iranian Crack-Related Withdrawal Pain | OMICS International | Abstract
ISSN: 2155-6105

Journal of Addiction Research & Therapy
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Research Article

A Randomized Double-Blind Pilot Trial of Gabapentin versus Placebo to Relieve Iranian Crack-Related Withdrawal Pain

Behnaz Behnam1*, Nadia Saghafi1, Raheb Ghorbani1, Mina Dianak Shoori1 and Mehrdad Sheikhvatan2

1Medical college, Semnan University of Medical Sciences, Semnan, Iran

2Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran

*Corresponding Author:
Behnaz Behnam
Medical college, Semnan University of Medical Sciences
Semnan, Iran.
Tel: 0231-3344768
Email: [email protected]

Received April 18, 2012; Accepted May 29, 2012; Published June 04, 2012

Citation: Behnam B, Saghafi N, Ghorbani R, Shoori MD, Sheikhvatan M (2012) A Randomized Double-Blind Pilot Trial of Gabapentin versus Placebo to Relieve Iranian Crack-Related Withdrawal Pain. J Addict Res Ther 3:125. doi:10.4172/2155- 6105.1000125

Copyright: © 2012 Behnam B, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Gabapentin seems to be a safe and well tolerated medication for treating cocaine dependence. This study examined the efficacy of gabapentin for withdrawal-related pain relief due to crack (the Iranian crack containing condensed heroin) use.
Sixty subjects were recruited from either an inpatient psychiatric ward of Fatemieh hospital in semnan and randomized to either placebo (n=30) or gabapentin (1800 mg/day) (n=30) for 7 days, balanced for gender. Subjective Opioid Withdrawal Scale was measured as a self-administered scale for grading body pain at baseline, and days 1, 2, 3, 4, 5, 6, and 7.
Mean of pain score had a significant decreasing trend in both gabapentin and placebo groups. Pain severity during the first six days of detoxification was significantly lower in gabapentin group compared with the controls, while the severity of pain based on SOWS scale was measured similar in the two groups at seventh day of trial.
We could confirm the effective role of gabapentin in removing Iranian crack-related withdrawal pain. However, this potential effect on pain removing was only observed in first six days of drug administration.


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