alexa Abdominal Stereotactic Body Radiotherapy: Local Control and Correlation to Biologically Equivalent Dose | OMICS International
ISSN:2167-7964

OMICS Journal of Radiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Abdominal Stereotactic Body Radiotherapy: Local Control and Correlation to Biologically Equivalent Dose

Simon Kirste1, Hans Trautsch1, Marc-Benjamin Messmer1, Rolf Wiehle1, Hans-Christian Rischke1, Felix Momm2, Anca-Ligia Grosu1 and Thomas B. Brunner1*
1Department of Radiation Oncology, University Hospitals Freiburg, Freiburg, Germany
2Department of Radiation Oncology, Ortenau Hospital Offenburg, Offenburg, Germany
*Corresponding Author : Thomas B Brunner
Department of Radiation Oncology
University Hospitals Freiburg, Freiburg, Germany
Tel: +49-761-270- 94070
E-mail: [email protected]
Received: February 11, 2016; Accepted: March 07, 2016; Published: March 10, 2016
Citation: Kirste S, Trautsch H, Messmer MB, Wiehle R,Rischke HC, et al. (2016) Abdominal Stereotactic Body Radiotherapy: Local Control and Correlation to Biologically Equivalent Dose. OMICS J Radiol 5:216. doi:10.4172/2167-7964.1000216
Copyright: © 2016 Brunner TB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aim: We conducted a retrospective study to report on the outcome and toxicity of stereotactic body radiotherapy (SBRT) and to analyze the correlation of local control (LC) and biological equivalent dose (BED) of patients treated with SBRT for upper abdominal lesions.

Methods: Patients who completed stereotactic radiotherapy treatment between 05/2007 and 03/2012 were enrolled into the analysis. Different fractionation regimens depending on the dose to organs at risk (OAR) were given. The primary endpoint was LC determined on imaging studies. Toxicities were classified according to CTCAE v4. Physical dose was converted into BED (α / β = 10 Gy) and a tumor control probability model (TCP) was used for dose-response relationship. For outcome analyses the Kaplan-Meier method and log rank tests were used.

Results: Forty-two patients were treated with SBRT. Thirty-three patients with 39 lesions were evaluable for further analysis with a median follow-up of 15.2 months. Lesions were located in liver (n = 28), hepatic hilum (n = 8), nodal (n = 2), adrenal (n = 2) and pancreatic head (n = 1). Local failure was observed in 7 lesions at a mean time of 7.3 months (range, 1.5 - 17.9) resulting in a LC rate of 83% at one year and 63% at two years. No significant difference for intra- vs extrahepatic lesions was observed. Lesions treated with a BED ≥ 59.5 Gy had a better LC vs. lesions treated with a BED < 59.5 Gy (88% vs. 68%, p = 0.027). Median overall survival was 14.5 months (2 - 32.5). Observed toxicities were mild (grade 2 in 4 patients, grade 3 in 1 patient).

Conclusion: Upper abdominal SBRT is well tolerated and results in excellent local control if BED is ≥ 59.5 Gy. We therefore propose to aim for doses at or above this BED.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version