alexa Age-related Changes of White Matter in the Elderly Population Measured by Diffusion Tensor Imaging | OMICS International | Abstract
ISSN:2167-7964

OMICS Journal of Radiology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Age-related Changes of White Matter in the Elderly Population Measured by Diffusion Tensor Imaging

Sheng-Heng Tsai1, Jachih Fu2, Jyh-Wen Chai1,3,4, Yi-Ying Wu1 and Clayton Chi-Chang Chen1,5,6,7*
1Department of Radiology, Taichung Veterans General Hospital, Taiwan
2Computer Aided Measurement and Diagnostic Systems Laboratory, Department of Industrial Engineering and Management, National Yunlin University of Science and Technology, Yunlin, Taiwan
3Division of Radiology, College of Medicine, China Medical University, Taichung, Taiwan
4Department of Biomedical Engineering, HungKuang University, Taichung, Taiwan
5Department of Radiological Technology and Graduate Institute of Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan
6Department of Physical Therapy, Hungkuang University of Technology, Taichung, Taiwan
7Department of Physical Therapy and Assistive Technology, National Yang Ming University, Taipei, Taiwan
Corresponding Author : Dr. Clayton Chi-Chang Chen
No 160, Sec 3, Taichung Harbor oad
Department of Radiology
Taichung Veterans General Hospital
Taichung, Taiwan
Tel: 04-23592525 ext 3701
Fax: 04-23592639
E-mail: [email protected]
Received July 23, 2012; Accepted August 19, 2012; Published August 22, 2012
Citation: Tsai SH, Fu J, Chai JW, Wu YY, Chen CCC (2012) Age-related Changes of White Matter in the Elderly Population Measured by Diffusion Tensor Imaging. OMICS J Radiology. 1:107. doi: 10.4172/2167-7964.1000107
Copyright: © 2012 Tsai SH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: A decline in cerebral White Matter (WM) integrity occurs across the adult lifespan, with more rapid degradation later in life. Diffusion Tensor Imaging (DTI) is a non-invasive method to evaluate the microscopic changes of WM in vivo. Linear regression models have been applied to depict the relationship between diffusion properties, such as Fractional Anisotropy (FA) and Mean Diffusivity (MD), derived from DTI and age. However, the fit of these linear regression models is unsatisfactory.

Objectives: The purpose of our study was to investigate the age-related changes of WM in an elderly population.

Methods: We performed statistical parametric mapping with DTI to evaluate the patterns of age-related microscopic WM changes with voxel-based analysis in the elderly population (>55 years old). A linear regression model was used to examine the associations between DTI parameters and age.

Results: The fit of the linear regression model depicting the association between mean global FA, MD values (FA, MD derived from global WM), and age was better than that reported in prior studies using DTI (R2=0.4252, p<0.001 for global FA and age; R2=0.5309, p<0.001 for global MD and age). Moreover, comparable to previous studies, the mean global FA showed a significant negative correlation with mean global MD, indicating a true age-related phenomenon of increased interstitial or intracellular fluid accumulation in cerebral WM. The mean frontal FA value was significantly lower than the mean global FA value. However, there was no significant difference between the mean frontal MD value and the mean global MD value.

Conclusions: Focusing on the elderly population, we can improve the fit of linear regression models to investigate the age-related changes of WM by DTI. These results suggest that age-related microscopic changes of WM might be occurring more consistently in later life.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7