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ISSN: 2332-0877

Journal of Infectious Diseases & Therapy
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Research Article

Amebic Liver Abscess is Associated with Malnutrition and Low Serum Leptin Level

Faisal Alam1*, Abdus Salam2, Iftekhar Mahmood3, Mamun Kabir1, Sharif Chowdhury4 and Rashidul Haque4

1Rajshahi Medical College, Bangladesh

2King Saud bin Abdulaziz University for Health Sciences, Jeddah, KSA

3Kushtia Medical College, Bangladesh

4Parasitology Laboratory, ICDDR.B, Dhaka, Bangladesh

*Corresponding Author:
Faisal Alam
Rajshahi Medical College, Bangladesh
E-mail: [email protected]

Received date: July 09, 2016; Accepted date: October 21, 2016; Published date: October 24, 2016

Citation: Alam F, Salam A, Mahmood I, Kabir M, Chowdhury S, et al. (2016) Amebic Liver Abscess is Associated with Malnutrition and Low Serum Leptin Level . J Infect Dis Ther 4:298. doi:10.4172/2332-0877.1000298

Copyright: © 2016 Alam F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and Objective: Amebic liver abscess (ALA), the most common form of extra-intestinal amebiasis is caused by the protozoan parasite E. histolytica. It is a prevalent parasitic infection in the northern region of Bangladesh for which hospital admission is required. The aim of this investigation was to explore the clinical spectrum of amebic liver abscess and its relationship with malnutrition and serum biomarker leptin.

Methods: The study population included 90 hospitalized ALA patients and 90 healthy controls during the period of July 2012 to June 2015. Liver abscess was diagnosed initially by ultrasound imaging and amebic liver abscess was confirmed by detection of E. histolytica DNA in abscess aspirates using a Real Time PCR. Body Mass Index (BMI) was measured conventionally for nutritional status and serum leptin was estimated by ELISA.

Results: Among the ALA cases (N=90), 37% had low BMI against only 3% of controls (N=90) [p<0.0001 at 95% CI]. About69 (76%) of low BMI patients had large or multiple liver abscess in comparison to 29% of standard BMI (p<0.0001 at 95% CI). Likewise, body fluid derangements such as edema, pleural effusion and ascites, either solitary or in combination were significantly higher (87% vs. 37%) among ALA with low BMI than standard BMI. Overwhelming majority of ALA patients 81(90%) was hypoleptinaemic.

Conclusion: Malnutrition and low serum leptin are important associations in amebic liver abscess patients with significance in disease outcomes.

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