Journal of Clinical & Experimental Pathology
Open Access

Review Article

An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component

¹Department of Pathology, University of Taif, Jeddah, Kingdom of Saudi Arabia

²Department of Surgery, MOH, King Fahad Hospital, Kingdom of Saudi Arabia

³Department of Pathology, Om Alqura University, Kingdom of Saudi Arabia

⁴Department of Radiology, MOH, King Fahad Hospital, Kingdom of Saudi Arabia

⁵Department of Medicine, MOH, Kingdom of Saudi Arabia

⁶Department of Surgery, MOH, Alnoor Hospital, Kingdom of Saudi Arabia

⁷Department of Medicine, University of Taief, Kingdom of Saudi Arabia

⁸Department of Medicine, King Abdulaziz Hospital, Kingdom of Saudi Arabia

⁹MOH, King Abdul Aziz Hospital, Kingdom of Saudi Arabia

*Corresponding Author:

Enaam Junainah
Department of Pathology, University of Taif
Jeddah, Kingdom of Saudi Arabia
Tel: 0096654442556
E-mail: mennastar3@yahoo.com

Received date: September 13, 2016; Accepted date: March 13, 2017; Published date: March 16, 2017

Citation: Junainah E, Baslaim M, Huwait HF, Shigairi S, Nemenqani D, et al. (2017) An Unusual Case of High Grade Triple Negative Intracystic Solid Papillary Carcinoma of Breast with Invasive Component. J Clin Exp Pathol 7:305. doi: 10.4172/2161-0681.1000305

Copyright: © 2017 Junainah E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Background: Intracystic (encysted) papillary carcinoma (IPC) is a rare distinct entity of breast cancer, usually asymptomatic, sometimes presented as breast mass or nipple discharge. It shows benign appearance on imaging. Ultrasonography shows pure cyst or mixed image, sometime solid mass. Pathologically can be divided into pure form, or associated with ductal carcinoma in situ (DCIS) or invasive carcinoma. It is considered as noninvasive or minimally invasive, because there is no infiltrating growth pattern and metastases are rare. Traditionally considered to lack a myoepithelial layer, it has favorable prognosis even with invasion. Stromal invasion found in 92%. In case of high grade variant which diagnosed by high nuclear grade and high mitotic activity, usually triple negative and p53+ as we have in our case?

Case presentation: We report a case of breast cancer that occurred in 42-year-old woman presented with a painless lump in the left breast, FNA yielded hemorrhagic fluid. Patient underwent wide local Excision. The final histopathological finding shows encapsulated/intra cystic carcinoma, papillary variant with high grade features, as defined by nuclear pleomorphic and increased mitotic activity. This tumor is also hormone receptor and HER-2- negative, and is associated with stromal invasion by high grade NOS.

Conclusion: High grade encapsulated papillary carcinoma is extremely rare variant, usually associated with invasive component; morphologically it is more aggressive. It behaves like its invasive counterpart.

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