Argonaute-1 Machinery Silent Cancer Noises
- *Corresponding Author:
- Manika Pal Bhadra
Centre for Chemical Biology, CSIRIndian Institute of Chemical Technology
Tel: 91 40 27193236
Email: [email protected]
- Utpal Bhadra
CSIR - Centre for Cellular and MolecularBiology
Tel: 91 40 27192513
E-mail: [email protected]
Received Date: February 01, 2016 Accepted Date: February 25, 2016 Published Date: March 03, 2016
Citation: Mondal T, Pal D, Bhadra MP, Bhadra U (2016) Argonaute-1 Machinery Silent Cancer Noises. Can surg 1:102.
Copyright: © 2016 Mondal T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Small non-coding RNA mediated that is micromanaging of global gene regulation was well established as fundamental principle in cell or tissue functions. To carry out, biological role small RNA needs a unique batch of protein family named Argonaute (AGO). The Argonaute proteins carry sophisticated and highly delicate interacting modules common for three specialized small RNAs, microRNA (miRNA), short interfering RNA (siRNA) and Piwi interacting RNA (piRNA). These RNA-proteins complexes are unique to coordinate silencing events in the genome. Recent works have made a novel role of AGO1 protein by extending its tentacle towards cancer monitoring pathways. It makes a constructive bridge between a direct and constructive link between cancer and RNAi (RNA interference) machinery. Apart from multifarious classical functions such as disruption of mRNA translation, decay, transcriptional regulation and splicing, we demonstrate a new concept to narrate the role of AGO1 proteins in different cancer regulatory pathways via microRNA- Argonaute circuit specifically.