Can Gemstone Spectral Imaging Accurately Determine the Concentration of Iodine Contrast: A Phantom Study
|Le Wang, Bin Liu*, Xing-wang Wu, Jie Wang, Wan-qin Wang, Yong Zhou, Xiao-hong Zhu, Zhang Shuai and Gao Na|
|Department of Radiology, the First Affiliated Hospital of AnHui Medical University, Hefei, Anhui Province 230022, China|
|Corresponding Author :||Liu Bin
218 JiXi Road, Department of Radiology
The First Affiliated Hospital of AnHui Medical University
Hefei, Anhui Province 230022, China
E-mail: [email protected]
|Received February 19, 2013; Accepted August 26, 2013; Published September 01, 2013|
|Citation: Wang L, Liu B, Wu XW, Wang J, Wang W, et al. (2013) Can Gemstone Spectral Imaging Accurately Determine the Concentration of Iodine Contrast: A Phantom Study. OMICS J Radiology 2:141 doi: 10.4172/2167-7964.1000141|
|Copyright: © 2013 Wang L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Purpose: To assess the accuracy of the quantification of the iodine concentration of contrast agent using gemstone spectral imaging under static and pulsating conditions respectively.
Methods: A phantom with nine test tubes containing iodine contrast in various concentrations (0.4, 0.7, 2.5, 10, 20, 30, 50 and 100 mg/ml) was scanned with gemstone spectral imaging mode of Discovery CT750 HD. All the scans were performed at static and pulsating status at gantry rotation time of 0.6 s, 0.8 s and 1.0 s respectively. Data were transferred to a work station to acquire iodine-based images, and the iodine contrast was measured within same-sized regions of interest at the same level. The relation and discrepancy between measured concentrations and real concentrations of the iodine contrasts were analyzed.
Results: At gantry rotation time of 0.8 s and 1.0 s, either at static status or pulsating status, the measured concentrations were significantly correlated with the real concentrations (p=0.000, r=0.999), without significant statistic difference (p>0.05). However, at gantry rotation time of 0.6 s, there was a statistically significant difference between the measured values and the real values (p<0.05), even though existed linear correlation between them (p=0.000, r=0.999).
Conclusions: Gemstone spectral imaging is a reliable method to accurately quantify the concentration of iodine contrasts, whatever at static or pulsating status at gantry rotation time of 0.8 s and 1.0 s. It therefore can be effectively used in differentiating lesions from normal issues.